Results 31 to 40 of about 136,068 (264)

Very High Cycle Fatigue (VHCF) of notched specimens: a review

Fracture and Structural Integrity
A large number of mechanical components are subjected to fatigue loading beyond 106 cycles. The VHCF behaviour of smooth specimens has been extensively investigated in the recent years, even if more efforts are necessary to reveal the mecahnism ...
Paolo Zuliani, Carlo Boursier Niutta, Davide Salvatore Paolino, Filippo Berto, Andrea Tridello   +4 more
doaj   +1 more source

Fatigue Probabilistic Approach of Notch Sensitivity of 51CrV4 Leaf Spring Steel Based on the Theory of Critical Distances

Applied Sciences
The mechanical and structural design of railway vehicles is heavily influenced by their lifetime. Because fatigue is a significant factor that impacts the longevity of railway components, it is imperative that the fatigue resistance properties of crucial
Vítor M. G. Gomes, Miguel A. V. de Figueiredo, José A. F. O. Correia, Abílio M. P. de Jesus   +3 more
doaj   +1 more source

Study of Secondary Effects of Fatigue Cracks in Cross Partitions of Steel Plate Reinforced Steel Box Girders

Applied Sciences, 2022
In order to investigate the effect of optimized reinforcement of cross-section of steel box girders with fatigue cracks on other vulnerable parts (cross-section, U-rib and deck slab, etc.) under wheel load, and to reveal the stress distribution law of ...
Yan Liu, Zhuoyi Chen, Jianbo Zeng, Chuanxi Li, Hui Peng, Youwei Gao   +5 more
doaj   +1 more source

AKAP200 promotes Notch stability by protecting it from Cbl/lysosome-mediated degradation in Drosophila melanogaster. [PDF]

PLoS Genetics, 2018
AKAP200 is a Drosophila melanogaster member of the "A Kinase Associated Protein" family of scaffolding proteins, known for their role in the spatial and temporal regulation of Protein Kinase A (PKA) in multiple signaling contexts. Here, we demonstrate an
Neeta Bala Tannan, Giovanna Collu, Ashley C Humphries, Ekatherina Serysheva, Ursula Weber, Marek Mlodzik   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effect of notch fillet radius on tensile strength of 817M40 notched bar

IOP Conference Series: Materials Science and Engineering, 2021
Abstract 817M40 steel is a popular grade of hardening alloy steel to its excellent machinability. It is manufactured the mechanical components like gears, shafts, studs and bolts. Its hardness in the range of 248/302 HB. In this paper, notch fillet radius effect on tensile loading was investigated.
Aditya Singh, Premanand S Chauhan, Prem Prakash Pandit, Manoj Narwariya   +3 more
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cis-interactions between Notch and its ligands block ligand-independent Notch activity

eLife, 2014
The Notch pathway is integrated into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation. Notch is further characterized by a twofold relationship with its Delta-Serrate
William Hunt Palmer, Dongyu Jia, Wu-Min Deng   +2 more
doaj   +1 more source

Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

Frontiers in Cell and Developmental Biology, 2022
Mechanical stimuli experienced by vascular smooth muscle cells (VSMCs) and mechanosensitive Notch signaling are important regulators of vascular growth and remodeling.
Cansu Karakaya, Cansu Karakaya, Mark C. van Turnhout, Valery L. Visser, Tommaso Ristori, Tommaso Ristori, Carlijn V. C. Bouten, Carlijn V. C. Bouten, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Sandra Loerakker, Sandra Loerakker   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source