Results 41 to 50 of about 9,549,485 (300)
Applied Sciences, 2022 In order to investigate the effect of optimized reinforcement of cross-section of steel box girders with fatigue cracks on other vulnerable parts (cross-section, U-rib and deck slab, etc.) under wheel load, and to reveal the stress distribution law of ...
Yan Liu +5 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Very High Cycle Fatigue (VHCF) of notched specimens: a review
Fracture and Structural IntegrityA large number of mechanical components are subjected to fatigue loading beyond 106 cycles. The VHCF behaviour of smooth specimens has been extensively investigated in the recent years, even if more efforts are necessary to reveal the mecahnism ...
Paolo Zuliani +4 more
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Effect of Notch Depth on the Fatigue Damage of Notched FRP Plates.
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1994 A fatigue failure criterion based on the concept of linear notch mechanics for predicting the fatigue life of notched FRP plates is subjected to further experimental scrutiny. An experimental program is presented which examines the effect of notch depth on the fatigue failure of notched FRP plates. This is accomplished by obtaining experimental data on
Hyakutake, Hiizu, Yamamoto, Toshihiro
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
CambridgeCentreForProteomics/notch: bioRxiv manuscript
, 2021 Analysis of a benchmark human:yeast dataset to examine the notch in TMT ...
Tom Smith
core +1 more source
Applied SciencesThe mechanical and structural design of railway vehicles is heavily influenced by their lifetime. Because fatigue is a significant factor that impacts the longevity of railway components, it is imperative that the fatigue resistance properties of crucial
Vítor M. G. Gomes +3 more
doaj +1 more source
AKAP200 promotes Notch stability by protecting it from Cbl/lysosome-mediated degradation in Drosophila melanogaster. [PDF]
PLoS Genetics, 2018 AKAP200 is a Drosophila melanogaster member of the "A Kinase Associated Protein" family of scaffolding proteins, known for their role in the spatial and temporal regulation of Protein Kinase A (PKA) in multiple signaling contexts. Here, we demonstrate an
Neeta Bala Tannan +5 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design Optimization and Experimental Study of CFRP Plate Anchorage with Clip-Extension Type
Zhongwai GongluExisting anchorage is prone to damaging the carbon-fiber reinforced polymer (CFRP) plate due to the “notch effect” and uneven distribution of clamping stress. This study proposed a new clip-extension type anchorage for the CFRP plate.
QI Yijia, XIAO Dan, WANG Zhongqiang
doaj +1 more source