Results 11 to 20 of about 136,068 (264)
The effects of notch size and material microstructure on the notch sensitivity factor for notched components [PDF]
Engineering Fracture Mechanics, 2015 Abstract Nickel base superalloys are used in hot sections of gas turbine engines due to its high strength and good creep, fatigue, and corrosion resistance at high temperature. In this paper, a new probabilistic approach based on weakest-link theory that accounts for the effects of the microstructure, notch size and notch acuity is described and ...
Gbadebo Owolabi +4 more
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Effects of Notch glycosylation on health and diseases [PDF]
Development, Growth & Differentiation, 2019 AbstractNotch signaling is an evolutionarily conserved signaling pathway and is essential for cell‐fate specification in metazoans. Dysregulation of Notch signaling results in various human diseases, including cardiovascular defects and cancer.
Yusuke Urata, Hideyuki Takeuchi
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Metals, 2019 This paper analyzes, using the theory of critical distances, the environmentally assisted cracking behavior of two steels (S420 and API X80) subjected to two different aggressive environments.
Pablo González +3 more
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Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle [PDF]
Open Biology, 2016 Glycolytic shift is a characteristic feature of rapidly proliferating cells, such as cells during development and during immune response or cancer cells, as well as of stem cells.
Vera Slaninova +6 more
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Stem Cell Research, 2021 Adipose tissue-derived stem cells (ADSCs) have been suggested as a novel treatment for non-alcoholic steatohepatitis (NASH); however, the mechanisms underlying their therapeutic effect remain poorly understood.
Kosuke Ishida +15 more
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Metals, 2021 The stress state has an important effect on the deformation and failure of metals. While the stress states of the axisymmetric notched bars specimens are studied in the literature, the studies on the flat metal specimen with inclined notch are very ...
Jian Peng +5 more
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A Method for Predicting the Effects of Specimen Geometry and Loading Condition on Fatigue Strength
Metals, 2018 Specimen geometry and loading condition usually have a great influence on the fatigue strength of metallic materials, which is an important issue in evaluating the reliability of component parts.
Chengqi Sun, Qingyuan Song
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The Role of Notch in the Cardiovascular System: Potential Adverse Effects of Investigational Notch Inhibitors [PDF]
Frontiers in Oncology, 2015 Targeting the Notch pathway is a new promising therapeutic approach for cancer patients. Inhibition of Notch is effective in the oncology setting because it causes a reduction of highly proliferative tumor cells and it inhibits survival of cancer stem cells, which are considered responsible for tumor recurrence and metastasis. Additionally, since Delta-
Paola eRizzo +10 more
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Scientific Reports, 2021 Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells.
Xueqing Chen, Mark M. Emerson
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Fatigue Crack Growth from Notches: A Numerical Analysis
Applied Sciences, 2020 A numerical approach based on plastic crack tip opening displacement (CTOD) was followed to study fatigue crack growth (FCG) from notches. The identification of fundamental mechanisms was made considering notched and unnotched models, with and without ...
Micael Borges +4 more
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