Results 121 to 130 of about 155,910 (299)

Targeting self-renewal pathways in myeloid malignancies [PDF]

, 2013
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core   +2 more sources

Soft Neural Interfaces for Circuit‐Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models

Advanced Healthcare Materials, EarlyView.
ABSTRACT Magnetogenetic deep brain stimulation (MG‐DBS) represents a wireless neuromodulation that has demonstrated long‐lasting behavioral benefits in Parkinson's disease models. However, the circuit‐level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces.
Jakyoung Lee, Yeongdo Lee, Enji Kim, Hunkyu Seo, Myoungjae Oh, Hanho Joo, Somin Lee, Jae‐Hyun Lee, Hyun Ho Jung, Minsuk Kwak, Jang‐Ung Park   +10 more
wiley   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer [PDF]

, 2017
Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor ...
Attwood, Kristopher, Chatta, Gurkamal, Granger, Victoria, Gueron, Geraldine, Guru, Khurshid, Hu, Qiang, Johnson, Candace, Krishnan, Nithya, McNally, Lacey, Morrison, Carl, Pili, Roberto, Rak, Monika, Ramakrishnan, Swathi, Smit, Evelyn, Wang, Dan, Wang, Jianmin, Woloszynska-Read, Anna   +16 more
core   +3 more sources

Tough, Ductile, and Strong Hard‐Soft Cementitious Composite Enabled by Multi‐Material Additive Manufacturing

Advanced Materials, EarlyView.
Drawing inspiration from the layered hard‐soft architecture found in sea sponges, this work establishes a new framework for architected cementitious composites (ACC) through multi‐material additive manufacturing (MMAM) process. The integration of mortar and elastomer phases into layered architectures enables synergistic toughening mechanisms, including
Aimane Najmeddine, Shashank Gupta, William Makinen, Zayvinn Lin, Krystal Delnoce, Reza Moini   +5 more
wiley   +1 more source

Multifaceted conserved functions of Notch during post-embryonic neurogenesis in the annelid Platynereis

EMBO Reports
Notch signaling is an evolutionarily conserved pathway known to orchestrate neurogenesis by regulating the transition from progenitors to neurons and glia, and by directing neurite outgrowth and axon guidance in many species. Although extensively studied
Loïc Bideau, Loeiza Baduel, Gabriel Krasovec, Caroline Dalle, Ombeline Lamer, Mélusine Nicolas, Alexandre Couëtoux, Corinne Blugeon, Louis Paré, Michel Vervoort, Pierre Kerner, Eve Gazave   +11 more
doaj   +1 more source

The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development [PDF]

, 2016
Long noncoding RNA (lncRNA) may contribute to the initiation and progression of tumor. In this study, we first systematically compared lncRNA and mRNA expression between glioblastoma and paired normal brain tissues using microarray data.
Eischen, Christine M., Fan, Wenhong, Liu, Shuang, Mitra, Ramkrishna, Yin, Feng, Zhao, Ming-Ming, Zhao, Zhongming   +6 more
core   +2 more sources

Triply‐Twinned Metamaterials: Unraveling the Mechanics and Failure Pathways Through High‐Resolution XCT

Advanced Materials, Volume 38, Issue 31, 2 June 2026.
Triply‐twinned architected lattices transform deformation from bending to stretching of struts, delivering up to threefold increases in stiffness and strength across polymeric and metallic systems. High‐resolution synchrotron XCT and image‐based simulations reveal how meta‐grain architecture, defects, and AM build orientation govern failure pathways ...
David McArthur, George Maddison, Jaianth Vijayakumar, Paul Tafforeau, Kathy Christofidou, Peter David Lee, PJ Tan, Chu Lun Alex Leung   +7 more
wiley   +1 more source

The Notch signaling pathway in hematopoiesis and hematologic malignancies

Haematologica, 2011
The Notch signaling pathway plays a critical role in the development and maintenance of embryonic and adult tissues. Notch signaling is initiated when a cell expressing an appropriate ligand interacts with another cell expressing a Notch receptor.
Ralf Schwanbeck, Ursula Just
openaire   +3 more sources

3D‐Printable, Honeycomb‐Inspired Tissue‐Like Bioelectrodes for Patient‐Specific Neural Interface

Advanced Materials, Volume 38, Issue 31, 2 June 2026.
3D printed MRI‐compatible tissue‐like neural electrodes tailored to individual gyral patterns. This honeycomb‐inspired printable gel electrode (HiPGE) employs a bioinspired architecture with soft hydrogels, engineered to match the softness of brain tissue.
Marzia Momin, Luyi Feng, Xiaoai Chen, Salahuddin Ahmed, Basma AlMahmood, Li‐Pang Huang, Jiashu Ren, Xinyi Wang, Hyunjin Lee, Samuel R. Cramer, Nanyin Zhang, Sulin Zhang, Tao Zhou   +12 more
wiley   +1 more source