Results 211 to 220 of about 93,970 (258)

The activation of the Notch signaling pathway by UBE2C promotes the proliferation and metastasis of hepatocellular carcinoma. [PDF]

Sci Rep
Zhan P, Lu Y, Lu J, Cheng Y, Luo C, Yang F, Xi W, Wang J, Cen X, Wang F, Xie C, Yin Z.   +11 more
europepmc   +1 more source

[Dll4/Notch signaling pathway and tumor angiogenesis.].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2009
Xinyu DING, Zhifei XU
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SRCAP is involved in porcine reproductive and respiratory syndrome virus activated Notch signaling pathway. [PDF]

J Virol
Ding G, Li Y, Li D, Dou M, Fu C, Chen T, Cui X, Zhang Q, Yang P, Hou Y, Liu S, Xiao Y.   +11 more
europepmc   +1 more source

Sinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the Notch signaling pathway. [PDF]

BMC Gastroenterol
Xu L, Liu W, Huang X, Sun T, Mei L, Liu M, Ren Z, Wang M, Zheng H, Wang Q, Li D, Wang Q, Ke X.   +12 more
europepmc   +1 more source

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Notch signaling pathway in pancreatic tumorigenesis

2023
The Notch signaling pathway is an evolutionary conserved signal transduction cascade that is critical to embryonic and postnatal development, but aberrant Notch signaling is also implicated in tumorigenesis of many organs including the pancreas. Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy in the pancreas, with a dismally low ...
Wen-Cheng, Chung, Keli, Xu
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Notch Signaling Pathway

Science's STKE, 2006
Notch is a receptor that mediates intercellular signaling through a pathway conserved across the metazoa. It is involved in cell fate assignation and pattern formation during development. The receptor acts as a membrane-tethered transcription factor and is activated by members of the Delta, Serrate, Lag-2 family of Notch ligands, which trigger two ...
Matthias, Ehebauer, Penelope, Hayward, Alfonso, Martinez-Arias   +2 more
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Dynamic Ligand Discrimination in the Notch Signaling Pathway [PDF]

Cell, 2018
The Notch signaling pathway comprises multiple ligands that are used in distinct biological contexts. In principle, different ligands could activate distinct target programs in signal-receiving cells, but it is unclear how such ligand discrimination could occur.
David Sprinzak, Nagarajan Nandagopal, Michael B Elowitz   +2 more
exaly   +5 more sources

Role of Notch Signaling Pathway in Glioblastoma Pathogenesis [PDF]

Cancers, 2019
Notch signaling is an evolutionarily conserved pathway that regulates important biological processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation. In mammals, Notch signaling is composed of four receptors (Notch1–4) and five ligands (Dll1-3–4, Jagged1–2) that mainly contribute to the development and maintenance ...
Angela Bentivegna, Riccardo Bazzoni, Bentivegna Angela   +2 more
exaly   +3 more sources

Notch signaling pathway and tissue engineering

Frontiers in Bioscience, 2007
The Notch pathway is a signaling network essential for proper organ development in an embryo, and is indispensable for tissue regeneration in the adult. This key regulatory signaling network is evolutionarily conserved in all metazoans and is continually utilized for the building, maintenance and repair of diverse organs and tissues.
Morgan E, Carlson, Matthew S, O'Connor, Michael, Hsu, Irina M, Conboy   +3 more
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Notch signalling pathway and human diseases

Seminars in Cell & Developmental Biology, 1998
Several homologs of the Drosophila Notch receptor and its ligands, Delta/Serrate, have been cloned in man. Three human disorders including a neoplasia (a T-cell acute lymphoblastic leukemia/lymphoma), a late onset neurological disease (CADASIL) and a developmental disorder (the Alagille syndrome) are associated with mutations in, respectively, the ...
A, Joutel, E, Tournier-Lasserve
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