Results 311 to 320 of about 156,496 (347)
Some of the next articles are maybe not open access.
Notch signalling: a simple pathway becomes complex
Nature Reviews Molecular Cell Biology, 2006A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells.
Sarah Bray
exaly +3 more sources
Science's STKE, 2006
Notch is a receptor that mediates intercellular signaling through a pathway conserved across the metazoa. It is involved in cell fate assignation and pattern formation during development. The receptor acts as a membrane-tethered transcription factor and is activated by members of the Delta, Serrate, Lag-2 family of Notch ligands, which trigger two ...
Matthias, Ehebauer +2 more
openaire +2 more sources
Notch is a receptor that mediates intercellular signaling through a pathway conserved across the metazoa. It is involved in cell fate assignation and pattern formation during development. The receptor acts as a membrane-tethered transcription factor and is activated by members of the Delta, Serrate, Lag-2 family of Notch ligands, which trigger two ...
Matthias, Ehebauer +2 more
openaire +2 more sources
Notch signalling pathway and human diseases
Seminars in Cell & Developmental Biology, 1998Several homologs of the Drosophila Notch receptor and its ligands, Delta/Serrate, have been cloned in man. Three human disorders including a neoplasia (a T-cell acute lymphoblastic leukemia/lymphoma), a late onset neurological disease (CADASIL) and a developmental disorder (the Alagille syndrome) are associated with mutations in, respectively, the ...
A, Joutel, E, Tournier-Lasserve
openaire +2 more sources
Notch signaling pathway and tissue engineering
Frontiers in Bioscience, 2007The Notch pathway is a signaling network essential for proper organ development in an embryo, and is indispensable for tissue regeneration in the adult. This key regulatory signaling network is evolutionarily conserved in all metazoans and is continually utilized for the building, maintenance and repair of diverse organs and tissues.
Morgan E, Carlson +3 more
openaire +2 more sources
Notch Signaling Pathway and Cancer Metastasis
2012Cancer metastasis is the leading cause of cancer-related deaths all over the world at present. Accumulated researches have demonstrated that cancer metastasis is composed of a series of successive incidents, mainly including epithelial-mesenchymal transition (EMT), malignant cell migration, resistance to anoikis, and angiogenesis and lymphangiogenesis ...
Yi-Yang, Hu +4 more
openaire +2 more sources
Notch Signaling Pathway in Ovarian Cancer
International Journal of Gynecological Cancer, 2009The literature is replete with reports of the paradoxical role of Notch signaling in human cancer. Notch appears to act as both an oncogene and a tumor suppressor gene depending on the cellular context. This review focuses on the nascent knowledge of Notch signaling in ovarian cancer. Despite advances in chemotherapy and radical surgery, ovarian cancer
openaire +2 more sources
Notch Signaling Pathway in Carcinogenesis
2018The Notch signaling pathway is a highly conserved pathway in most multicellular organisms. It is of critical importance for cell proliferation, differentiation, and homeostasis. Aberrant Notch signaling can give rise to a number of pathologies including cancer.
Andrei Zlobin +3 more
openaire +1 more source
An overview of the Notch signalling pathway
Seminars in Cell & Developmental Biology, 2003The Notch receptor plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species. Four Notch homologues have been identified in the human genome and aberrant Notch function has been associated with a number of human diseases.
openaire +2 more sources
Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms
Current Opinion in Genetics & Development, 2008Despite a relatively simple core-signaling transduction machinery, Notch signaling controls cell differentiation in many different tissues and at multiple stages in a given cell lineage. To understand how Notch generates this multitude of cellular responses, it is important to learn how the Notch-signaling output is modulated at various levels. Pathway-
Lorenz, Poellinger, Urban, Lendahl
openaire +2 more sources
Targeting the Notch signaling pathway in autoimmune diseases
Expert Opinion on Therapeutic Targets, 2010The Notch signaling pathway regulates a variety of processes and has been linked to diverse effects. Aberrant Notch function is important in several disorders. Pre-clinical studies have suggested that inhibition of Notch is an attractive approach to treat hematologic and solid malignancies.
Daoxin, Ma +3 more
openaire +2 more sources