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Notch signalling pathway and human diseases
Journal of Hepatology, 2000Notch-l mutation (TAN-l) and T-cell lymphoblastic leukaemia Mutation of the human Notch1 was identified through the observation of a chromosomal translocation t(7;9) from tumour cells of three cases of human T lymphoblastic leukaemia. The breakpoint occurs within 100 bp of an intron of Notchl.
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Notch 1 signaling pathway effect on implantation competency
Fertility and Sterility, 2011To investigate the relationship between the Notch 1 signaling pathway and the embryo implantation rate.Mouse embryos were cultured in vitro, and implantation competency was quantified.Tertiary fertility center of a university teaching hospital.Outbred ICR strain mouse embryos.The expression of Notch 1 was altered by adding a γ-secretase inhibitor to ...
Po-Wei, Chu +4 more
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Wnt and Notch signaling pathways selectively regulating hematopoiesis
Annals of Hematology, 2010Hematopoietic stem and progenitor cells (HSPCs) are the source of all blood cells in the adult body. The pool of HSPCs is formed during embryogenesis process through a well-characterized succession of intra-embryonic regions and organs. The spatial and temporal restrictions in definitive hematopoietic development and the signaling molecules involved ...
Kun, Zhou +6 more
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[Notch signaling pathway and multiple myeloma].
Zhongguo shi yan xue ye xue za zhi, 2011Notch signaling pathway is a main pathway through cell-cell interactions, which regulates the programmed cell death, cellular proliferation and differentiation in multiple cell systems, and also is an important signaling pathway to modulate the balance between proliferation and differentiation in hematopoietic environment, and is related with the ...
Zhi-Hua, Gan, Yu, Chen
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SEPT4 is regulated by the Notch signaling pathway
Molecular Biology Reports, 2011Notch receptor-mediated signaling is an evolutionarily conserved pathway that regulates diverse developmental processes and its dysregulation has been implicated in a variety of developmental disorders and cancers. Notch functions in these processes by activating expression of its target genes.
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Notch signal pathway and tumor
Academic Journal of Second Military Medical University, 2009Jian LIU, Kui WANG, Feng SHEN
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End-to-end design of wearable sensors
Nature Reviews Materials, 2022, Peter Q Nguyen, Laura Gonzalez-Macia
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The adenosine pathway in immuno-oncology
Nature Reviews Clinical Oncology, 2020Bertrand Allard +2 more
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Lineage plasticity in cancer: a shared pathway of therapeutic resistance
Nature Reviews Clinical Oncology, 2020Helena A Yu +2 more
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