Results 251 to 260 of about 26,639 (292)
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2018
Cellular senescence, previously thought of as an autonomous tumour suppressor mechanism, is emerging as a phenotype and effector present throughout the life of an organism from embryogenesis to senile decline. Senescent cells have powerful non-autonomous effects upon multiple players within their microenvironment mainly through their secretory ...
Hoare, Matthew, Narita, Masashi
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Cellular senescence, previously thought of as an autonomous tumour suppressor mechanism, is emerging as a phenotype and effector present throughout the life of an organism from embryogenesis to senile decline. Senescent cells have powerful non-autonomous effects upon multiple players within their microenvironment mainly through their secretory ...
Hoare, Matthew, Narita, Masashi
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Current Opinion in Genetics & Development, 1997
Homologs of the Notch receptor and its ligands participate in cell fate decisions during vertebrate development. The past year has seen significant advances in knowledge of the role of Notch in Xenopus neuronal development and T-cell development and in our understanding of the Notch signalling pathway in vertebrates.
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Homologs of the Notch receptor and its ligands participate in cell fate decisions during vertebrate development. The past year has seen significant advances in knowledge of the role of Notch in Xenopus neuronal development and T-cell development and in our understanding of the Notch signalling pathway in vertebrates.
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Journal of Neuroscience Research, 1998
The Notch signaling pathway has during the last few years emerged as an important signaling mechanism for communication between neighboring cells. Many of the components in the Notch signaling pathway have been identified and the pathway is important for cellular differentiation in various organs, including the nervous system.
P, Beatus, U, Lendahl
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The Notch signaling pathway has during the last few years emerged as an important signaling mechanism for communication between neighboring cells. Many of the components in the Notch signaling pathway have been identified and the pathway is important for cellular differentiation in various organs, including the nervous system.
P, Beatus, U, Lendahl
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Science, 1995
The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans . Studies on the expression, mutant phenotypes, and developmental consequences of unregulated receptor activation have implicated these proteins
S, Artavanis-Tsakonas +2 more
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The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans . Studies on the expression, mutant phenotypes, and developmental consequences of unregulated receptor activation have implicated these proteins
S, Artavanis-Tsakonas +2 more
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Trends in Neurosciences, 2005
Some of the signaling molecules required for formation of long-term memories are involved primarily in adult brain function, but others participate in a variety of other biological processes. The Notch signaling pathway, which is important for cell fate specification and differentiation in various systems, is also active in the mature brain.
Rui M, Costa +2 more
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Some of the signaling molecules required for formation of long-term memories are involved primarily in adult brain function, but others participate in a variety of other biological processes. The Notch signaling pathway, which is important for cell fate specification and differentiation in various systems, is also active in the mature brain.
Rui M, Costa +2 more
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2018
Notch is commonly activated in lymphoid malignancies through ligand-independent and ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), ligand-independent activation predominates. Negative Regulatory Region (NRR) mutations trigger supraphysiological Notch1 activation by exposing the S2 site to proteolytic cleavage in ...
Anna C, McCarter +2 more
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Notch is commonly activated in lymphoid malignancies through ligand-independent and ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), ligand-independent activation predominates. Negative Regulatory Region (NRR) mutations trigger supraphysiological Notch1 activation by exposing the S2 site to proteolytic cleavage in ...
Anna C, McCarter +2 more
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2005
How do we take XP to the next level? How do we get respect and freedom to work as we'd like? How do we get them to listen to us? XP has successfully raised expectations for what is technically possible with software development. The next challenge is realizing that potential.
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How do we take XP to the next level? How do we get respect and freedom to work as we'd like? How do we get them to listen to us? XP has successfully raised expectations for what is technically possible with software development. The next challenge is realizing that potential.
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Deciphering Notch signaling notch by notch
Cell Signaling, 2023Lidia Borkiewicz, Adolfo Rivero-Müller
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Nature Medicine, 2000
Constitutive activation of Notch signaling in hematopoietic cells establishes an immortalized hematopoietic stem cell population capable of developing into both myeloid and lymphoid lineages. This system will be useful in determining Notch-mediated mechanisms of hematopoietic differentiation (pages 1278–1281
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Constitutive activation of Notch signaling in hematopoietic cells establishes an immortalized hematopoietic stem cell population capable of developing into both myeloid and lymphoid lineages. This system will be useful in determining Notch-mediated mechanisms of hematopoietic differentiation (pages 1278–1281
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