Results 261 to 270 of about 23,253 (298)
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Journal of Neuroscience Research, 1998
The Notch signaling pathway has during the last few years emerged as an important signaling mechanism for communication between neighboring cells. Many of the components in the Notch signaling pathway have been identified and the pathway is important for cellular differentiation in various organs, including the nervous system.
P, Beatus, U, Lendahl
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The Notch signaling pathway has during the last few years emerged as an important signaling mechanism for communication between neighboring cells. Many of the components in the Notch signaling pathway have been identified and the pathway is important for cellular differentiation in various organs, including the nervous system.
P, Beatus, U, Lendahl
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2018
Notch is commonly activated in lymphoid malignancies through ligand-independent and ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), ligand-independent activation predominates. Negative Regulatory Region (NRR) mutations trigger supraphysiological Notch1 activation by exposing the S2 site to proteolytic cleavage in ...
Anna C, McCarter +2 more
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Notch is commonly activated in lymphoid malignancies through ligand-independent and ligand-dependent mechanisms. In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL), ligand-independent activation predominates. Negative Regulatory Region (NRR) mutations trigger supraphysiological Notch1 activation by exposing the S2 site to proteolytic cleavage in ...
Anna C, McCarter +2 more
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Trends in Neurosciences, 2005
Some of the signaling molecules required for formation of long-term memories are involved primarily in adult brain function, but others participate in a variety of other biological processes. The Notch signaling pathway, which is important for cell fate specification and differentiation in various systems, is also active in the mature brain.
Rui M, Costa +2 more
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Some of the signaling molecules required for formation of long-term memories are involved primarily in adult brain function, but others participate in a variety of other biological processes. The Notch signaling pathway, which is important for cell fate specification and differentiation in various systems, is also active in the mature brain.
Rui M, Costa +2 more
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2018
Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the neurons of the adult brain. However, neurogenesis continues throughout life at distinct locations in the vertebrate brain. Neural stem cells (NSCs) are the origin of both embryonic and adult neurogenesis, but their activity and fate are ...
Engler A, Zhang R, Taylor V
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Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the neurons of the adult brain. However, neurogenesis continues throughout life at distinct locations in the vertebrate brain. Neural stem cells (NSCs) are the origin of both embryonic and adult neurogenesis, but their activity and fate are ...
Engler A, Zhang R, Taylor V
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Current Opinion in Genetics & Development, 1997
Homologs of the Notch receptor and its ligands participate in cell fate decisions during vertebrate development. The past year has seen significant advances in knowledge of the role of Notch in Xenopus neuronal development and T-cell development and in our understanding of the Notch signalling pathway in vertebrates.
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Homologs of the Notch receptor and its ligands participate in cell fate decisions during vertebrate development. The past year has seen significant advances in knowledge of the role of Notch in Xenopus neuronal development and T-cell development and in our understanding of the Notch signalling pathway in vertebrates.
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Deciphering Notch signaling notch by notch
Cell Signaling, 2023Lidia Borkiewicz, Adolfo Rivero-Müller
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2005
How do we take XP to the next level? How do we get respect and freedom to work as we'd like? How do we get them to listen to us? XP has successfully raised expectations for what is technically possible with software development. The next challenge is realizing that potential.
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How do we take XP to the next level? How do we get respect and freedom to work as we'd like? How do we get them to listen to us? XP has successfully raised expectations for what is technically possible with software development. The next challenge is realizing that potential.
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Nature Medicine, 2000
Constitutive activation of Notch signaling in hematopoietic cells establishes an immortalized hematopoietic stem cell population capable of developing into both myeloid and lymphoid lineages. This system will be useful in determining Notch-mediated mechanisms of hematopoietic differentiation (pages 1278–1281
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Constitutive activation of Notch signaling in hematopoietic cells establishes an immortalized hematopoietic stem cell population capable of developing into both myeloid and lymphoid lineages. This system will be useful in determining Notch-mediated mechanisms of hematopoietic differentiation (pages 1278–1281
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