Results 111 to 120 of about 38,174 (285)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Temps d'Educació, 2011 Un dels aspectes de la cultura material de l'escola i de la història educativa, en la seva concepció més global, contínuament present en els diferents espais pedagògics, ha estat el relatiu a l'activitat lúdica.
Andrés Payà Rico
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Els nous materials s'inspiren en taurons i flors
, 2013 Els nous materials sintètics, els més revolucionaris, s"inspiraran en la natura, capaç de crear per ella mateixa estructures amb propietats ...
openaire +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Nous desenvolupaments en materials per vertebroplàstia [PDF]
, 2018 Increasing life expectancy is leading to an increase in age-related diseases, like osteoporosis, which often involve the breakdown of bone. One of the main problems related with such disease is the formation of vertebral compression fractures (VCF).
Borrós, Salvador, Bardají, Sara
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Fachadas pré-fabricadas em argamassa reforçada com fibra de vidro em três estudos de caso na grande Porto Alegre [PDF]
, 2006 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Arquitetura e UrbanismoAs fachadas pré-fabricadas em GRC (Glassfibre Reinforced Concrete) são formadas por painéis leves, em argamassa ...
Vefago, Luiz Henrique Maccarini
core
Els agresomes, nou material biofuncional en nanomedicina i biotecnologia
, 2015 Los cuerpos de inclusión bacterianos son materiales proteicos nanoestructurados con aplicaciones biomédicas como la entrega de fármacos o las topografías biofuncionales. Sin embargo, muchas enzimas con posibles aplicaciones biomédicas o industriales no pueden ser producidas en sistemas bacterianos.
openaire +1 more source