Results 81 to 90 of about 210,426 (300)
Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein [PDF]
, 2008 Background: Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD).
Czirr, Eva +8 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
El grafè: un nou material electrònic [PDF]
, 2010 Un material de Nobel : El grafeno es un material revolucionario que cuenta entre sus propiedades el ser transparente, buen conductor, flexible y barato que ha dejado sorprendido a la sociedad científica y que ha valido a sus investigadores el Nobel de Física.
openaire
Surgical concepts for reconstruction of the auricle [PDF]
, 1986 We compiled and evaluated the world literature on auricular reconstruction, for a total of over 400 publications, more than 200 authors, and over 3,300 reported cases. We found that partial reconstructions were already performed as early as 600 BC; total
Berghaus, Alexander, Toplak, F.
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Health Research in AfricaIntroduction. Inter-arm blood pressure difference (IAD) is a well-established clinical practice worldwide. However, the relationship between IAD and cardiovascular disease is not well known.
Fatouma Sall +4 more
doaj +1 more source
El caràcter transfigurable dels objectes digitals
Artnodes, 2011 A causa de l'augment d'internet i del que és digital, cada vegada hi ha més patrimoni cultural que adopta la forma d'operacions basades en les TIC, cosa que contradiu les pràctiques i els arxius tradicionals.
Attila Márton
doaj +1 more source
Unconscious Thought in Peripatetic Philosophy [PDF]
, 2014 In Aristotle’s De anima 3.5, the relation between intellect and thought, and between thought and object, is not accessible to discursive or conscious thought; an understanding of the relation requires nous, intuitive or “unconscious” thought. The “active”
Hendrix, John S
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source