Results 81 to 90 of about 6,190,445 (297)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2022 This book is inspired by the quest for the proper function of Aristotle’s active intellect presented in "De Anima 3.5". The urge to grasp its essence has always driven philosophy ahead. Nevertheless, the true nature of nous poitikos remains far from being grasped. I will not unravel it here either, I am afraid. My aim is far more modest: to get through
openaire +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
LA INMIGRACIÓN: UN FENÓMENO NATURAL, CONVERTIDO EN PROBLEMA
Didáctica Geográfica, 2011 RESUMEN: Una de les características que singularizan el siglo XXI es el fenómeno de la interculturalidad en un mundo globalizado que ha roto fronteras a través de las nuevas tecnologías y las comunicaciones, pero donde al mismo tiempo los países más ...
Enric Ramiro i Roca
doaj
Access and Advocacy: Text & Data Mining and DMCA §1201
Digital StudiesSignificant work in DH has focused on access, labor, and infrastructure. They fundamentally shape the field, from who is included to what we study (for example, see Graban et al 2019, McGrail et al 2022, and Losh and Wernimont 2018). Often less discussed
Lauren Tilton, Quinn Dombrowski
doaj +2 more sources
Oil & Gas Science and Technology, 2006 Thermal coupling of methane or methane pyrolysis, which is a possible way for the direct chemical conversion of natural gas, can be used to produce ethylene, acetylene and benzene.
Weill J. +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source