Results 41 to 50 of about 660 (176)

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

FQ Circini: An Ordinary Nova with a High-mass B1 V(n)(e) Companion Whose Decretion Disk Transfers Mass to the White Dwarf via Roche–Lobe Overflow

The Astrophysical Journal
FQ Cir was an ordinary fast He/N classical nova, peaking at V = 10.9. The pre-eruption and post-eruption counterpart was at V = 14.0, making this the smallest known classical nova amplitude, 3.1 mag.
Bradley E. Schaefer, Andrew Pearce, Tom Love, Michael M. Shara, Lee Townsend, Simon J. Murphy, Christopher J. Corbally   +6 more
doaj   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Injectable Chondroitin Sulfate Methacrylate Hydrogel Microspheres Co‐Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
A multifunctional injectable microsphere system is fabricated via UV‐assisted microfluidic cross‐linking, integrating nanozyme‐based ROS scavenging, sustained dexamethasone release, and stem cell delivery. Upon IA injection, the microspheres adapt to joint stress, suppress inflammation, and promote cartilage regeneration, offering a minimally invasive ...
Xiaochen Feng, Ying Fang, Hongwei Yu, Yicheng Wang, Yunze Xu, Chunxiao Shi, Haike Xia, Ranjith Kumar Kankala, Aizheng Chen, Shibin Wang, Chaoping Fu   +10 more
wiley   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Nanoimprinted DMD Electrodes Enabling Bidirectional Viewing OLEDs With Quasi Lambertian Emission

Advanced Science, EarlyView.
We present a dual‐approach strategy for high‐performance bidirectional‐viewing OLEDs, combining enhanced cavity resonance with a nanoimprinted dielectric/metal/dielectric (DMD) electrode. This bidirectional viewing OLED presents an 89.7% enhanced electrode transmittance, a balanced bidirectional emission ratio with 67.3% total brightness increase, as ...
Ningning Song, Ningning Liang, Xinghao Guo, Ruixiang Chen, Xia Xin, Yiming Chen, Ruiqi Tian, Tianrui Zhai   +7 more
wiley   +1 more source

Understanding the Roles of Microstructure and Viscoelasticity of Soft Ionic Elastomer for Super‐Capacitive Pressure Sensors

Advanced Science, EarlyView.
By engineering the PVA/H3PO4 ionic elastomer with optimized viscoelasticity and a height‐graded microstructure, the pressure sensor achieves a broad linear range up to 2000 kPa and a high sensitivity of 2.70 nF/kPa. These advancements underscore its strong potential for wearable electronics, including bio‐signal detection, health monitoring, and ...
Allen J. Cheng, Wenkai Chang, Zhuohan Cao, Zhao Sha, Shuai He, Ming Xuan Chua, Bingnong Jiang, Yuansen Qiao, Ziyan Gao, Wenkui Dong, Wengui Li, Liao Wu, Dewei Chu, Shuhua Peng   +13 more
wiley   +1 more source

Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy

Advanced Science, EarlyView.
An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo, Xiaoyan Guo, Jian Wei, Miaowen Jiang, Qifa Su, Xian Xia, Zhuozhou Li, Rong Cai, Jianguo Ma, Bo Fu, Ming Li, Jing Zhong, Lijun Xu, Xunming Ji   +13 more
wiley   +1 more source

Combining the Pitcher and Lotus Plant: Supericephobic and Superhydrophobic Silicone Films

Advanced Science, EarlyView.
Based on bench‐top nanomolding of polydimethylsiloxane (PDMS) with optimized silicone oil content, we developed hierarchically structured silicone films by essentially combining the properties of the lotus and pitcher plant; particularly we are able to achieve water contact angle as high as 171° and ice adhesion strength as low as 11.5 kPa (i.e ...
Cliff L. W. Ng, Joshua Ham, Sanpreet Kaur, Clayton W. Schultz, Hua‐Zhong Yu   +4 more
wiley   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source