Results 211 to 220 of about 17,241,247 (352)

Revolutionizing microbial treasure troves: innovative strategies for natural products discovery. [PDF]

Nat Prod Bioprospect
Li YJ, Qiu MH, Peng XR.
europepmc   +1 more source

Novel methods improve prediction of species' distributions from occurrence data

, 2006
J. Elith, Catherine H. Graham, Robert P. Anderson, Miroslav Dudı́k, Simon Ferrier, A. Guisan, R. Hijmans, F. Huettmann, J. Leathwick, Anthony Lehmann, Jin Li, Lúcia G. Lohmann, Bette A. Loiselle, G. Manion, Craig Moritz, Miguel Nakamura, Yoshinori Nakazawa, J. M. Overton, A. T. Peterson, Steven J. Phillips, Karen Richardson, R. Scachetti-Pereira, R. Schapire, Jorge Soberón, Stephen Williams, M. Wisz, Niklaus E. Zimmermann   +26 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Comprehensive genome analysis uncovers the diversity of jumbo phages in the pig gut microbiome. [PDF]

Front Vet Sci
Wei C, Chen Z.
europepmc   +1 more source

Identification of a novel coronavirus in patients with severe acute respiratory syndrome.

New England Journal of Medicine, 2003
C. Drosten, S. Günther, W. Preiser, S. van der Werf, H. Brodt, S. Becker, H. Rabenau, M. Panning, L. Kolesnikova, R. Fouchier, A. Berger, A. Burguière, J. Cinatl, M. Eickmann, N. Escriou, Klaus Grywna, S. Kramme, J. Manuguerra, S. Müller, V. Rickerts, M. Stürmer, Simon Vieth, H. Klenk, A. Osterhaus, H. Schmitz, H. Doerr   +25 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

FluoNeRF: Fluorescent Novel-View Synthesis Under Novel Light Source Colors and Spectra. [PDF]

J Imaging
Shi L, Matsufuji K, Yoshida M, Kawahara R, Okabe T.   +4 more
europepmc   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Clinical application of a novel rib fracture score system in patients with multiple rib fractures. [PDF]

Front Surg
Zhang J, Li W, Liu Z.
europepmc   +1 more source