Results 71 to 80 of about 23,570,152 (294)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Novel view synthesis using needle-map correspondence [PDF]

, 2002
Interest in view interpolation and novel view synthesis is growing. In this paper we show how dense correspondence can be found between needle-maps generated using shape-from-shading, which in turn can be used to generate new needle-maps.
Philip L. Worthington, P.L. Worthington
core   +1 more source

Adaptive Deletion of Gaussian Ellipsoids in 3D Gaussian Splatting

Mathematics
As a leading method for Novel View Synthesis (NVS), 3D Gaussian Splatting (3DGS) faces limitations. Fixed thresholds governing Gaussian scale and opacity lead to over-reconstruction or under-reconstruction, while the linear penalty used for handling ...
Fei Zhang, Yinghui Wang, Bo Yi, Jiaxin Ma   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Arbitrary Optics for Gaussian Splatting Using Space Warping

Journal of Imaging
Due to recent advances in 3D reconstruction from RGB images, it is now possible to create photorealistic representations of real-world scenes that only require minutes to be reconstructed and can be rendered in real time.
Jakob Nazarenus, Simin Kou, Fang-Lue Zhang, Reinhard Koch   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Rethinking 3-D Scene Evaluation From an Object-Centric Perspective

IEEE Access
This paper proposes Detectability Score (D-score), a novel evaluation metric for 3D scenes that emphasizes evaluating individual objects within the scenes.
Yuiko Uchida, Ren Togo, Keisuke Maeda, Takahiro Ogawa, Miki Haseyama   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Learning Unified Decompositional and Compositional NeRF for Editable Novel View Synthesis

, 2023
Implicit neural representations have shown powerful capacity in modeling real-world 3D scenes, offering superior performance in novel view synthesis. In this paper, we target a more challenging scenario, i.e., joint scene novel view synthesis and editing
Wu, Wayne, Xu, Dan, Wang, Yuxin
core   +1 more source