Results 41 to 50 of about 170 (132)

Evaluation of critical parameters in the hollow‐fibre system for tuberculosis: A case study of moxifloxacin

open access: yesBritish Journal of Clinical Pharmacology, Volume 90, Issue 7, Page 1711-1727, July 2024.
Aims The hollow‐fibre system for tuberculosis (HFS‐TB) is a preclinical model qualified by the European Medicines Agency to underpin the anti‐TB drug development process. It can mimic in vivo pharmacokinetic (PK)–pharmacodynamic (PD) attributes of selected antimicrobials, which could feed into in silico models to inform the design of clinical trials ...
Diana A. Aguilar‐Ayala   +10 more
wiley   +1 more source

Non‐m6A RNA modifications in haematological malignancies

open access: yesClinical and Translational Medicine, Volume 14, Issue 6, June 2024.
Non‐m6A RNA modifications play critical roles in haematological malignancies. Gaps exist in understanding of non‐m6A modifications and their regulatory mechanisms in blood cancers. Emerging studies show non‐m6A modification regulators as potential prognostic markers and therapeutic targets in blood malignancies.
Meiling Chen   +4 more
wiley   +1 more source

Infinito y sustracción en "Qué hacer" de Pablo Katchadjian: lo novelesco en el horizonte neoliberal

open access: yesAnclajes, 2022
La novela experimental Qué hacer (2010) de Pablo Katchadjian está tramada por un procedimiento de repetición y combinatoria que monta, de modo imprevisible y desenfrenado, diferentes escenarios, objetos, acciones y personajes.
Victoria Cóccaro
doaj  

YBX1 Promotes Esophageal Squamous Cell Carcinoma Progression via m5C‐Dependent SMOX mRNA Stabilization

open access: yesAdvanced Science, Volume 11, Issue 20, May 28, 2024.
Liu et al. identify that YBX1, an m5C reader protein, is upregulated in ESCC tissues. Further, YBX1 promotes ESCC progression by stabilizing SMOX mRNA and consequently activating the mTOCR1 signaling pathway in an NSUN2‐mediated m5C modification‐dependent manner.
Liwen Liu   +12 more
wiley   +1 more source

Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis

open access: yesMedComm, Volume 5, Issue 4, April 2024.
Inflammatory retinal microglia with high expression of Cd74 and Ccl5 are identified at the disease peak of experimental autoimmune uveitis (EAU) by single‐cell RNA sequencing. Targeting Cd74 and Ccl5 effectively alleviated microglial activation and disease phenotype in the EAU model .
Jiangyi Liu   +9 more
wiley   +1 more source

“Our study offers insight into…” Rhetorical promotion in English and Spanish conference abstracts

open access: yesInternational Journal of Applied Linguistics, Volume 34, Issue 1, Page 134-149, February 2024.
Abstract The conference abstract (CA) is an important promotional academic genre that allows scholars to introduce their research to their peers as a conference presentation if the proposal is accepted by the reviewing gatekeepers. However, few studies have explored the CA in specific disciplines and no studies have examined this genre from an ...
Pedro Martín, Sally Burgess
wiley   +1 more source

THE ORIGINS OF FLANN O’BRIEN’S AT SWIM- TWO-BIRDS

open access: yesES Review, 2017
At Swim-Two-Birds, la primera novela de Flann O'Brien publicada en 1939, ha sido generalmente considerada como la obra maestra de Flann O'Brien debido a su narración espontánea y su estilo experimental.
Germán Asensio Peral
doaj  

Creation, intersubjectivity and the novel: Unamuno on life in Cómo se hace una novela

open access: yesOrbis Litterarum, Volume 79, Issue 1, Page 77-89, February 2024.
Abstract This article shows that, in Miguel de Unamuno, both philosophy and literature contribute to an intellectual project that has to do with life. I will argue that Unamuno, in Cómo se hace una novela, presents a philosophy of life that understands human life as an intersubjective creation.
Katrine Helene Andersen
wiley   +1 more source

Reseña - Jorge Bracamonte: Por una teoría desde la novela experimental argentina hasta 1980

open access: yesConfabulaciones, 2022
Jorge Bracamonte teoriza alrededor de las problemáticas de la novela experimental, de ruptura, de vanguardia, realizando un recorrido a través de una selección de obras, de autores de la literatura argentina, retrocediendo su mirada a décadas de grandes cambios en el siglo XX, a partir de los ’40, de los ’60 hasta 1980, como bien refiere en el título ...
openaire   +1 more source

María Dolores Blanco Arnejo: La novela lúdica experimental de Julio Cortázar: Madrid, Editorial Pliegos, Colección Pliegos de ensayo. 1997. 224 págs.

open access: yesEstudios filológicos, 1998
Un prefacio de la autora enumera características, objetivos y pasos metodológicos de "un estudio ecléctico" cuyo corpus de investigación incluye 62. Modelo para armar (1968); Libro de Manuel (1973), Los autonautas de la cosmopista (1984), obras publicadas por Cortázar después de Rayuela (1963).
openaire   +3 more sources

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