Results 21 to 30 of about 121 (107)
MINFLUX nanoscopy: Visualising biological matter at the nanoscale level
Journal of Microscopy, Volume 298, Issue 2, Page 219-231, May 2025.Abstract Since its introduction in 2017, MINFLUX nanoscopy has shown that it can visualise fluorescent molecules with an exceptional localisation precision of a few nanometres. In this overview, we provide a brief insight into technical implementations, fluorescent marker developments and biological studies that have been conducted in connection with ...
Alexander Carsten +2 more
wiley +1 more source
Engaging youth in biodiversity education through visual narrative
Conservation Biology, Volume 38, Issue 6, December 2024.Abstract Engaging youth in early and sustained conservation education has important implications for promoting positive attitudes and behaviors in those who will become the future of conservation and management. Toward this goal, visual narratives (comic books, graphic novels) are an increasingly popular method used by conservation scientists to ...
Kyra Ricci +3 more
wiley +1 more source
SLCO1B1 and ABCG2 genotype‐informed phenotypes are related to variation in ramipril exposure
Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 3, Page 295-307, September 2024.Abstract Ramipril is an angiotensin‐converting enzyme inhibitor used for hypertension and heart failure management. To date, scarce literature is available on pharmacogenetic associations affecting ramipril. The goal of this study was to investigate the effect of 120 genetic variants in 34 pharmacogenes (i.e., genes encoding for enzymes like CYPs or ...
Houwaida Abbes +12 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 90, Issue 7, Page 1711-1727, July 2024.Aims The hollow‐fibre system for tuberculosis (HFS‐TB) is a preclinical model qualified by the European Medicines Agency to underpin the anti‐TB drug development process. It can mimic in vivo pharmacokinetic (PK)–pharmacodynamic (PD) attributes of selected antimicrobials, which could feed into in silico models to inform the design of clinical trials ...
Diana A. Aguilar‐Ayala +10 more
wiley +1 more source
Non‐m6A RNA modifications in haematological malignancies
Clinical and Translational Medicine, Volume 14, Issue 6, June 2024.Non‐m6A RNA modifications play critical roles in haematological malignancies. Gaps exist in understanding of non‐m6A modifications and their regulatory mechanisms in blood cancers. Emerging studies show non‐m6A modification regulators as potential prognostic markers and therapeutic targets in blood malignancies.
Meiling Chen +4 more
wiley +1 more source
Advanced Science, Volume 11, Issue 20, May 28, 2024.Liu et al. identify that YBX1, an m5C reader protein, is upregulated in ESCC tissues. Further, YBX1 promotes ESCC progression by stabilizing SMOX mRNA and consequently activating the mTOCR1 signaling pathway in an NSUN2‐mediated m5C modification‐dependent manner.
Liwen Liu +12 more
wiley +1 more source
Single‐cell RNA sequencing reveals inflammatory retinal microglia in experimental autoimmune uveitis
MedComm, Volume 5, Issue 4, April 2024.Inflammatory retinal microglia with high expression of Cd74 and Ccl5 are identified at the disease peak of experimental autoimmune uveitis (EAU) by single‐cell RNA sequencing. Targeting Cd74 and Ccl5 effectively alleviated microglial activation and disease phenotype in the EAU model .
Jiangyi Liu +9 more
wiley +1 more source
“Our study offers insight into…” Rhetorical promotion in English and Spanish conference abstracts
International Journal of Applied Linguistics, Volume 34, Issue 1, Page 134-149, February 2024.Abstract The conference abstract (CA) is an important promotional academic genre that allows scholars to introduce their research to their peers as a conference presentation if the proposal is accepted by the reviewing gatekeepers. However, few studies have explored the CA in specific disciplines and no studies have examined this genre from an ...
Pedro Martín, Sally Burgess
wiley +1 more source
Creation, intersubjectivity and the novel: Unamuno on life in Cómo se hace una novela
Orbis Litterarum, Volume 79, Issue 1, Page 77-89, February 2024.Abstract This article shows that, in Miguel de Unamuno, both philosophy and literature contribute to an intellectual project that has to do with life. I will argue that Unamuno, in Cómo se hace una novela, presents a philosophy of life that understands human life as an intersubjective creation.
Katrine Helene Andersen
wiley +1 more source
Estudios filológicos, 1998 Un prefacio de la autora enumera características, objetivos y pasos metodológicos de "un estudio ecléctico" cuyo corpus de investigación incluye 62. Modelo para armar (1968); Libro de Manuel (1973), Los autonautas de la cosmopista (1984), obras publicadas por Cortázar después de Rayuela (1963).
openaire +3 more sources