Results 91 to 100 of about 210,711 (296)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Girls Just Want To Have Fun: The Portrayal of Girls’ Rebellion in Mobile Phone Novels
, 2017 The rise of kētai shōsetsu—digital novels written and shared on mobile phones, predominantly by girls—in the late 2000s caught the attention of Japanese critics and journalists, as a new literary phenomenon that was taking the world of Japanese girls ...
Marie Kim
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
ANALISIS NILAI PENDIDIKAN KARAKTER PADA NOVEL “SEPATU DAHLAN“ KARYA KHRISNA PABICHARA
Jurnal PAJAR (Pendidikan dan Pengajaran), 2019 This study aims to describe the value of character education contained in the novel “Sepatu Dahlan” by Khrisna Pabichara. The subject of this research is the novel “Sepatu Dahlan” Karya Khrisna Pabichara published by the publisher Noura Books (Mizan ...
Ovi Pratama
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Religious Moderation Based on Local Wisdom
AsketikReligious moderation is a perspective, behavior and attitude that always chooses a position in the middle, is always based on justice, and does not take an extreme position in religious practice. four indicators of religious moderation, namely tolerance,
Puji Laksono
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Cuadernos LIRICOThe article proposes to investigate the way in which an approach to literary relations from the perspective of socio-historical translation studies configures the building of a corpus and an archive that maintains dense relations with the one built by ...
Ana Eugenia Vazquez
doaj +1 more source