Results 191 to 200 of about 272,983 (311)

Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression. [PDF]

BMJ Open
Bhargava M, Crouser ED, Barkes BQ, Weise DO, Perlman DM, Epperson LE, Griffin TJ, Jagtap PD, Mehta S, Li L, Leach SM, Maier LA.   +11 more
europepmc   +1 more source

The np-completeness column: Finding needles in haystacks

, 2007
This is the 26th edition of a column that covers new developments in the theory of NP-completeness. The presentation is modeled on that which M. R. Garey and I used in our book “Computers and Intractability: A Guide to the Theory of NP-Completeness, ” W.
David S. Johnson
core  

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Metagenome-assembled genomes, and gene and protein catalogues from the global wild boar faecal microbiome. [PDF]

Sci Data
Heng YC, Dagar SS, Fliegerova K, Moniello G, Ikeda-Ohtsubo W, Okuda K, Kittelmann S.   +6 more
europepmc   +1 more source

The NP-Completeness Column: The Many Limits on Approximation

, 2006
This is the 25th edition of a column that covers new developments in the theory of NP-completeness. The presentation is modeled on that which M. R. Garey and I used in our book “Computers and Intractability: A Guide to the Theory of NP-Completeness, ” W.
David S. Johnson
core  

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Evaluation of the first nutritional psychiatry and psychosomatics outpatient clinic: Protocol for a prospective study of an individualized biopsychosocial therapy approach. [PDF]

PLoS One
Mörkl S, Ramirez-Obermayer A, DelFabro B, Lackner S, Holasek S, Traub J, Größbacher K, Brandstätter A, Wilding M, Wagner-Skacel J.   +9 more
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Enhancing screening, early diagnosis and treatment initiation of oral, breast and cervical cancer in selected districts of India: an implementation research protocol. [PDF]

BMJ Open
Kankaria A, Shukla P, Vijayakumar M, Sachdeva A, Subramanian MJ, Borah PK, Sahoo SS, Nirgude A, Prusty RK, T S S, Asuri K, Verma P, Sharma J, Dhaliwal RS, Begum S, Kaur T, ICMR-NHRP Cancer Screening Group.   +16 more
europepmc   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source