Results 201 to 210 of about 272,983 (311)

Nurses' Roles, Challenges, and Reported Outcomes in Rural and Remote Healthcare: A JBI-Aligned Scoping Review (PRISMA-ScR). [PDF]

Healthcare (Basel)
Aljuhani M, Dakhilallah H, Alyahya NM, Alharbi BS, Almutairi A, Alshehri WM, Eid T, Alodhailah AM.   +7 more
europepmc   +1 more source

On the Complexity of the Highway Pricing Problem

The highway pricing problem asks for prices to be determined for segments of a single highway such as to maximize the revenue obtainable from a given set of customers with known valuations. The problem is (weakly) NP-hard and a recent quasi-PTAS suggests
Uetz, Marc, Loon, Joyce van, Grigoriev Alexander   +2 more
core  

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Dynamic multiplex cytokine profiling to identify risk factors for Lung Consolidation and Necrotizing Transformation in Children with <i>Mycoplasma Pneumoniae</i> Pneumonia. [PDF]

Mediterr J Hematol Infect Dis
Yan H, Zhang C.
europepmc   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Tight Approximation and Kernelization Bounds for Vertex-Disjoint Shortest Paths. [PDF]

Theory Comput Syst
Bentert M, Fomin FV, Golovach PA.
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Coexisting Type 2 Inflammatory Conditions in Patients with Asthma Treated with Dupilumab: the RAPID Registry. [PDF]

Adv Ther
Peters AT, Côté A, Muñoz X, Xia C, Nash S, Hardin M, de Prado Gómez L, Sacks HJ, Jacob-Nara JA, Rowe PJ, Deniz Y.   +10 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Development of VP30-targeted nanoparticles using DPS4 fusion peptides for the inhibition of Ebola virus. [PDF]

J Nanobiotechnology
Wu F, Huang Y, Li R, Gao P, Lv P, Wu G, Ma Y, Ding Q, Zhong J, Su J, Xu W.   +10 more
europepmc   +1 more source