Results 61 to 70 of about 37,420 (268)
NSC348884 cytotoxicity is not mediated by inhibition of nucleophosmin oligomerization
Scientific Reports, 2021 Nucleophosmin (NPM) mutations causing its export from the nucleoli to the cytoplasm are frequent in acute myeloid leukemia (AML). Due to heterooligomerization of wild type NPM with the AML-related mutant, the wild-type becomes misplaced from the nucleoli
Markéta Šašinková +7 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
A Knowledge‐Based Approach for Understanding and Managing Additive Manufacturing Data
Advanced Engineering Materials, EarlyView.Additive manufacturing processes generate a large amount of data. Effectively managing, understanding, and retrieving information from this data remains a major challenge. Therefore, we propose an ontology‐based approach to integrate heterogeneous data, enable semantic queries, and support decision‐making.
Mina Abd Nikooie Pour +5 more
wiley +1 more source
Ultra-deep mutational analysis of NPM-ALK and possible implications on target therapy in anaplastic large cell lymphoma of childhood [PDF]
, 2013 Anaplastic Large Cell Lymphoma (ALCL) represents a distinct subset of aggressive T-cell non-Hodgkin lymphoma (NHL) accounting for about 3% of adult NHL and 10 to 15% of childhood lymphomas.
Lovisa, Federica
core
Governance, rational choice and new public management (npm): a general view (and some critics) [PDF]
, 2019 This article aims to study the New Public Management (NPM), one of the main trends associated to neoliberalism. It studies governance to show its general, wider and abstract scope.
de Oliveira Fornasier, M., Franklin, S.
core +1 more source
MUI FATWA NO.83/2023: ITS IMPACT ON THE PROFITABILITY OF COMPANIES AFFILIATED WITH ISRAEL
I-FinanceThe purpose of this study is to determine and analyze the differences in profitability as measured by ROA, ROE, and NPM between before and after the boycott according to MUI fatwa No. 83 of 2023.
Annisa Maulidiana, Trischa Relanda Putra
doaj +1 more source
National Science Open, 2023 Non-precious metal single-atom catalysts (NPM-SACs) with unique electronic structures and coordination environments have gained much attention in electrocatalysis owing to their low cost, high atomic utilization, and high performance.
Liu Li-Xia +11 more
doaj +1 more source
Advanced Science, EarlyView.This work develops a soft hybrid electronic system with printed thermoresponsive hydrogel electrodes, which enables high‐fidelity neural signal acquisition and stimulation. The system precisely assesses median and ulnar nerve injuries in clinical cases, realizing accurate diagnosis of neural impairment while ensuring customized adhesion regulation ...
Bo Pang +13 more
wiley +1 more source
Russian Journal of Economics and Law, 2019 Objective: to formulate the principles of reforming the industry and to identify the relationship between the universities reorganization and the indicators of socio-economic development of a region.Methods: questionnaires, in-depth interviews ...
A. I. Maskaev, P. O. Savko
doaj +1 more source
Advanced Science, EarlyView.A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang +7 more
wiley +1 more source