Results 41 to 50 of about 44,465 (272)

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Spatial patterns of MODIS-NPP (A) and DLEM-simulated NPP (B) during 2000–2009 and comparison of the DLEM-simulated NPP with MODIS-NPP (C) for 6000 randomly selected grids.

, 2014
Spatial patterns of MODIS-NPP (A) and DLEM-simulated NPP (B) during 2000–2009 and comparison of the DLEM-simulated NPP with MODIS-NPP (C) for 6000 randomly selected grids.
Jia Yang (427274), Xiaoke Wang (548086), Bowen Zhang (595078), Shufen Pan (558238), Hanqin Tian (314078), Zhiyun Ouyang (662246), Chi Zhang (9857), Kamaljit Banger (662247), Qichun Yang (314077), Shree R. S. Dangal (662245), Wei Ren (267391), Chaoqun Lu (558237), Bo Tao (558236), Xia Li (14984)   +13 more
core   +1 more source

NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin

, 2022
DNA viruses are responsible for many diseases in humans. Current treatments are often limited by toxicity, as in the case of cidofovir (CDV, Vistide), a compound used against cytomegalovirus (CMV) and adenovirus (AdV) infections.
Aaron M. Chadderdon (14240514), Ann E. Tollefson (13802965), Matthew K. Doherty (14240520), Caroll B. Hartline (14240529), Mark N. Prichard (252944), John M. Domagala (2521279), Kim M. Hutchings (6599891), Xinmin Gan (2004670), Andrew D. White (1842340), Cheryl C. Harteg (14240517), Elke Lipka (14240511), Eric S. Simon (14240523), David I. Bernstein (8099324), William S. M. Wold (14240538), Emma A. Harden (3364058), Kathy A. Keith (2497426), Scott H. James (14240532), Jacqueline F. Spencer (14240535), Dawn M. Reyna (14240526), Rhonda D. Cardin (3385631), Karoly Toth (785339)   +20 more
core   +1 more source

Estimation of the efficiency of combining a npp with a hydrogen facility under conditions of safe use of hydrogen in a steam turbine cycle

Известия высших учебных заведений: Проблемы энергетики, 2021
THE PURPOSE. System efficiency and competitiveness assess of a new scheme for combining a nuclear power plant with a hydrogen complex based on additional heating of feed water and superheating of live steam in front of the high-pressure cylinder of a ...
R. Z. Aminov, A. N. Bairamov
doaj   +1 more source

Assessing the accuracy and stability of variable importance in species distribution modelling algorithms through sample perturbations

Ecography, EarlyView.
Variable importance derived from species distribution modelling (SDM) is widely used to identify key environmental drivers of species distributions. However, the reliability of these inferences has rarely been systematically evaluated, particularly with respect to their sensitivity to individual occurrences.
He Wu, Zhaoning Wu, Yunzhi Liu, Wenfang Zhang, Jiechen Wang   +4 more
wiley   +1 more source

Spatiotemporal Distribution of Carbon Sink Indicators—NPP and Its Driving Analysis in Ordos City, China

, 2023
Ordos City is an important energy supply city for Chinese provinces and cities, providing a secure energy supply for China while also generating corresponding environmental pollution. Examining the spatiotemporal patterns of net primary productivity (NPP)
Wenbin Sun, Deqin Fan, Linye Zhu, Jianfei Wu   +3 more
core   +1 more source

Phenotypic and transcriptomic characterization of biallelic RNU2‐2 developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective A significant proportion of individuals with suspected genetic developmental and epileptic encephalopathies (DEEs) remain unsolved following whole genome sequencing (WGS). Here we describe biallelic RNU2‐2 variants causing a recently reported, severe, recessive DEE.
Olivia J. Henry, Nadja Pekkola Pacheco, Irene Duba, Magnus Burstedt, Daniel Carlberg, Angelica M. Delgado‐Vega, Anna Hammarsjö, Sofie Ivarsson, Tord Jonson, Kristina Karrman, Nicole Lesko, Åsa Lindfors, Daniel Nilsson, Mia Olsson Engman, Lucía Peña‐Pérez, Erik Stenund, Fulya Taylan, Malin Ueberschär, Samuel Wiafe, Sofia Ygberg, Anna Lindstrand, Anna Wedell, Ann Nordgren, Tommy Stödberg   +23 more
wiley   +1 more source

A Multi‐Software Approach to Assessing Photovoltaics Integration in Modern Enovoltaic Systems

Energy Science &Engineering, EarlyView.
Robust eno‐PV design methodology applied to a real case study Multi‐software 3D model developed to optimize PV panels‐vineyard configuration Energy yield nearly independent of tracker height, but reduced by wider row spacing Grape productivity improving with height and decreasing with spacing Energy generation and grape yield balanced by tuning PV ...
Erika Stracqualursi, Gianfranco Di Lorenzo, Rodolfo Araneo, Francesco Grimaccia   +3 more
wiley   +1 more source

The percentage of seasonal NPP in the among of annual NPP from 1986 to 2015.

, 2019
The percentage of seasonal NPP in the among of annual NPP from 1986 to 2015.
Wen Shen (624469), Xueding Jiang (6940766), Xiaoyan Bai (554943)   +2 more
core   +1 more source

Enhancing Resilience through Nuclear Emergency Preparedness at El Dabaa Site

Science and Technology of Nuclear Installations
The research utilized advanced PCTRAN and RASCAL software to evaluate the potential radiological impacts of hypothetical accidents, specifically loss-of-coolant accident (LOCA) and long-term station blackout (LTSBO), at the El Dabaa Nuclear Power Plant ...
Waad Saleh, Juyoul Kim
doaj   +1 more source