Results 71 to 80 of about 414,208 (359)

Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

eLife, 2018
Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors.
Romain Durand-de Cuttoli, Sarah Mondoloni, Fabio Marti, Damien Lemoine, Claire Nguyen, Jérémie Naudé, Thibaut d'Izarny-Gargas, Stéphanie Pons, Uwe Maskos, Dirk Trauner, Richard H Kramer, Philippe Faure, Alexandre Mourot   +12 more
doaj   +1 more source

Dopaminergic and prefrontal dynamics co-determine mouse decisions in a spatial gambling task

Cell Reports, 2023
Summary: The neural mechanisms by which animals initiate goal-directed actions, choose between options, or explore opportunities remain unknown. Here, we develop a spatial gambling task in which mice, to obtain intracranial self-stimulation rewards, self-
Elise Bousseyrol, Steve Didienne, Samir Takillah, Clement Prevost-Solié, Maxime Come, Tarek Ahmed Yahia, Sarah Mondoloni, Eléonore Vicq, Ludovic Tricoire, Alexandre Mourot, Jérémie Naudé, Philippe Faure   +11 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

NaGdF4:Eu3+ Nanoparticles for Enhanced X-ray Excited Optical Imaging. [PDF]

, 2014
X-ray luminescent nanoparticles (NPs), including lanthanide fluorides, have been evaluated for application to deep tissue in vivo molecular imaging using optical tomography.
Cena, Jake, Cherry, Simon, Das, Gautom K, Kennedy, Ian M, Li, Changqing, Stark, Daniel, Sudheendra, L   +6 more
core   +1 more source

Comparison of Algorithms for Clustering Incomplete Data

Foundations of Computing and Decision Sciences, 2014
The missing values are not uncommon in real data sets. The algorithms and methods used for the data analysis of complete data sets cannot always be applied to missing value data.
Matyja Artur, Siminski Krzysztof
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy [PDF]

, 2015
The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy.
Bahrami, B., Bakhshaei, P., Ghalamfarsa, G., Hojjat-Farsangi, M., Jadidi-Niaragh, F., Mohammadnia-Afrouzi, M., Sadreddini, S., Yazdani, Y., Yousefi, M.   +8 more
core   +1 more source

Dopamine builds and reveals reward-associated latent behavioral attractors

Nature Communications
Phasic variations in dopamine levels are interpreted as a teaching signal reinforcing rewarded behaviors. However, behavior also depends on the motivational, neuromodulatory effect of phasic dopamine.
Jérémie Naudé, Matthieu X. B. Sarazin, Sarah Mondoloni, Bernadette Hannesse, Eléonore Vicq, Fabrice Amegandjin, Alexandre Mourot, Philippe Faure, Bruno Delord   +8 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Transcript expression of vesicular glutamate transporters in lumbar dorsal root ganglia and the spinal cord of mice – Effects of peripheral axotomy or hindpaw inflammation [PDF]

, 2013
Using specific riboprobes, we characterized the expression of vesicular glutamate transporter (VGLUT)1–VGLUT3 transcripts in lumbar 4–5 (L4–5) dorsal root ganglions (DRGs) and the thoracolumbar to lumbosacral spinal cord in male BALB/c mice after a 1- or
Brumovsky, Pablo Rodolfo, Gebhart, G. F., Hökfelt, T., Lundgren, K. H., Malet, Mariana, Seal, R. P., Seroogy, K. B., Tomasella, María Eugenia, Vieytes, C. A.   +8 more
core   +1 more source