Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Protein Tyrosine Phosphatases (PTPs) regulate cellular signaling by balancing phosphotyrosine levels through a conserved WPD‐loop that switches between open (inactive) and closed (active) conformations. While this conformational change is crucial for catalysis, the structural factors governing this motion remain poorly understood.
Colin L. Welsh, Lalima K. Madan
wiley +1 more source
Near-peer versus faculty member teaching in endocrine physiology: Medical students' academic achievement and satisfaction. [PDF]
J Educ Health PromotMahmudi P +3 more
europepmc +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The E2 domain of amyloid precursor protein (APP_E2) plays a central role in the protein's function. We reinvestigate how the missense mutation, ΔH382L, affects the domain's thermal stability and ligand binding propensity through differential scanning fluorometry.
Sphamandla Ndlovu +4 more
wiley +1 more source
Informal Near-Peer Teaching Effects on Medical Student Pre-Clinical Learning. [PDF]
Med Sci EducHall RP +3 more
europepmc +1 more source
Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri +2 more
wiley +1 more source
CRISPR/Cas9-based gene-editing platform development by targeting genes encoding magnesium chelatase and phytoene desaturase in sugarbeet (<i>Beta vulgaris</i> L.). [PDF]
Front Genome EdKhan ZA +5 more
europepmc +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to evolve and diversify, leading to the emergence of immune‐evasive variants and underscoring the need for complementary antiviral strategies targeting conserved viral machinery. In this context, the main protease (Mpro) represents a potential therapeutic target because
David Ferreiro, Miguel Arenas
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The Impact of Digitalization on European General Practice From the Perspective of General Practitioners: Systematic Review. [PDF]
J Med Internet ResFuger JM, Niehoff L, Zelko E.
europepmc +1 more source
Phytotherapy Research, EarlyView.Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei +4 more
wiley +1 more source
Enhancing Relative Binding Free Energy Calculation with Grand Canonical Monte Carlo, Water-swap Monte Carlo, Terminal-flip Monte Carlo and Replica Exchange Solute Tempering. [PDF]
J Chem Theory ComputHui C, de Groot BL.
europepmc +1 more source