Results 71 to 80 of about 104,757 (302)

Effects of Secukinumab on Enthesiophyte and Erosion Progression in Psoriatic Arthritis: A One‐Year Double‐Blind, Randomized, Placebo‐Controlled Trial Using High‐Resolution Peripheral Quantitative Computed Tomography

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by using high‐resolution peripheral quantitative computed tomography (HR‐pQCT). Methods This was a phase 4, double‐blind, randomized, placebo‐controlled trial.
Yingzhao Jin, Isaac T. Cheng, Ho So, Billy T. Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk‐Chun Szeto, Jack J. Lee, Ling Qin, Lai‐Shan Tam   +11 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Ex Vivo Permeation of Carprofen Vehiculated by PLGA Nanoparticles through Porcine Mucous Membranes and Ophthalmic Tissues

Nanomaterials, 2020
(1) Background: Carprofen (CP), 2-(6-chlorocarbazole) propionic acid, is used as an anti-inflammatory, analgesic and anti-pyretic agent and it belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs).
Lídia Gómez-Segura, Alexander Parra, Ana Cristina Calpena-Campmany, Álvaro Gimeno, Immaculada Gómez de Aranda, Antonio Boix-Montañes   +5 more
doaj   +1 more source

Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a “hit‐and‐run” paradigm

Cancer Communications, EarlyView.
Abstract Background Helicobacter pylori (H. pylori) infection contributes significantly to gastric cancer (GC) progression. The intrinsic mechanisms of H. pylori‐host interactions and their role in promoting GC progression need further investigation.
Bing He, Yiyang Hu, Yuyun Wu, Chao Wang, Limin Gao, Chunli Gong, Zhibin Li, Nannan Gao, Huan Yang, Yufeng Xiao, Shiming Yang   +10 more
wiley   +1 more source

Niosome as a promising tool for increasing the effectiveness of anti-inflammatory compounds

EXCLI Journal : Experimental and Clinical Sciences
Niosomes are drug delivery systems with widespread applications in pharmaceutical research and the cosmetic industry. Niosomes are vesicles of one or more bilayers made of non-ionic surfactants, cholesterol, and charge inducers.
Mohammad Saleh Fadaei, Mohammad Reza Fadaei, Amir Emad Kheirieh, Pouria Rahmanian-Devin, Mohammad Mahdi Dabbaghi, Kiarash Nazari Tavallaei, Abouzar Shafaghi, Hooman Hatami, Vafa Baradaran Rahimi, Ali Nokhodchi, Vahid Reza Askari   +10 more
doaj   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Nonsteroidal anti-inflammatory drug administration to periparturient cows to reduce postpartum pain-related behaviours

Veterinary Evidence
Question In periparturient cows does the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) aid in reducing pain-related behaviours after parturition when compared to cows not administered NSAIDs?
Amelia Cannadine
doaj   +1 more source

Measuring prevalence, reliability and variation in high-risk prescribing in general practice using multilevel modelling of observational data in a population database

Health Services and Delivery Research, 2015
Background: High-risk primary care prescribing is common and is known to vary considerably between practices, but the extent to which high-risk prescribing varies among individual general practitioners (GPs) is not known.
Bruce Guthrie, Ning Yu, Douglas Murphy, Peter T Donnan, Tobias Dreischulte   +4 more
doaj   +1 more source

Chemical Characterization of Alphitonia neocaledonica (Schltr.) Guillaumin Bark Extract and Its Anti‐Inflammatory Activities

Chemistry &Biodiversity, EarlyView.
Study of the anti‐inflammatory activities and chemical characterization of Alphitonia neocaledonica (Schltr.) Guillaumin bark extract. ABSTRACT Alphitonia neocaledonica (Schltr.) Guillaumin is a small forest tree endemic of New Caledonia traditionally used to treat rheumatic pain and dermatoses.
Karl Huet, Philippe Georgel, Mohammed Nour, Mohamed Haddad, Edouard Hnawia, Mariko Matsui   +5 more
wiley   +1 more source