Results 81 to 90 of about 245,924 (389)
Advanced Science, EarlyView.Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang +6 more
wiley +1 more source
Ibrain, EarlyView., 2023 This study compared the clinical effectiveness and treatment satisfaction of Pregabalin and Gabapentin triple therapy for neuropathic pain in a real‐world setting. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from baseline to 12 weeks posttreatment.
Nithya Raju +7 more
wiley +1 more source
Health Services and Delivery Research, 2015 Background: High-risk primary care prescribing is common and is known to vary considerably between practices, but the extent to which high-risk prescribing varies among individual general practitioners (GPs) is not known.
Bruce Guthrie +4 more
doaj +1 more source
EVALUATION OF PROHYPERTENSIVE EFFECT OF MELOXICAM ON THE BLOOD PRESSURE INDICATORS
Архивъ внутренней медицины, 2019 The goal is to evaluate the influence of meloxicam on the level of blood pressure among patients suffering from hypertension, as well as among patients without diseases of the cardiovascular system, in relation to its pro-hypertensive effect.Materials ...
R. V. Nikiforov +2 more
doaj +1 more source
Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay [PDF]
, 2013 Objectives: Lead antituberculosis (anti-TB) molecules with novel mechanisms of action are urgently required to fuel the anti-TB drug discovery pipeline.
Bhakta, Sanjib +9 more
core +1 more source
Advanced Science, EarlyView.This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv +8 more
wiley +1 more source
The good use of NSAID: when, why and how
Pathos, 2019 Non-steroidal anti-inflammatory drugs (NSAIDs) are the first line treatment of acute or recurrent pain and often remain the prerogative of the primary care physician if not the patient himself on self-administration.
Gianluca Conversa
doaj
Utilization of Analgesics among Adults in Alexandria
Journal of High Institute of Public Health, 2015 Background: Rational use of medicine can be defined as receiving medications appropriate to the clinical needs, in doses that meet the individual requirements and for an adequate period of time.
Engy Hussein, Zahira Gad, Iman Wahdan
doaj +1 more source
Вісник проблем біології і медицини, 2019 The article investigated changes in the level of CTX I marker under the influence of non-steroidal antiinflammatory drugs and paracetamol under experimental equivalents of hypothyroidism and osteoarthritis.
Nosivets D. S.
doaj +1 more source
Use of a glycosamine sulfate for patients with osteoarthritis and a comorbidity with high risk of the side effects from NSAIDS [PDF]
Терапевтический архив, 2018 The literature review is devoted to the peculiarities of treating co-morbid patients with acute conditions of chronic pain. The proved effect of NSAIDS must always correlate with the side effect risk.
A V Naumov, O N Tkacheva
doaj +1 more source