Results 121 to 130 of about 355,709 (346)

Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases. [PDF]

, 1996
Douglas A. Arenberg, S L Kunkel, Peter J. Polverini, S. B. MORRIS, Marie D. Burdick, Mary Glass, D T Taub, Mark D. Iannettoni, Richard I. Whyte, Robert M. Strieter   +9 more
openalex   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source

Long Noncoding RNA LINC01426 Sequesters microRNA-519d-5p to Promote Non-Small Cell Lung Cancer Progression by Increasing ETS1 Expression

Cancer Management and Research, 2020
Jixin Dai,1 Bing Wang,2 Yueming Zhao,1 Xuerong Zuo,1 Hongxia Cui,1 Xi Chen,2 Xianhong Liu1 1Department of Oncology, Jilin Cancer Hospital, Changchun, Jilin 130000, People’s Republic of China; 2Department of Radiotherapy, Jilin Cancer Hospital ...
Dai J, Wang B, Zhao Y, Zuo X, Cui H, Chen X, Liu X   +6 more
doaj  

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

Advanced Science, EarlyView.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
wiley   +1 more source

LncRNA GATA6-AS1 Inhibits the Progression of Non-Small Cell Lung Cancer via Repressing microRNA-543 to Up-Regulating RKIP

Cancer Management and Research, 2020
Zixuan Gong,1,* Xiaoyu Chen,2,* YueChao Zhang,3,* Cheng Liu,4 Zhibing Wang,5 Xiaoyan Xu,6 Jun Zhu,7 Tongqing Xue4 1Department of Urology, Jiangsu Provincial People’s Hospital, Nanjing, Jiangsu Province, 211166, People’s Republic of China ...
Gong Z, Chen X, Zhang Y, Liu C, Wang Z, Xu X, Zhu J, Xue T   +7 more
doaj  

EMT-Mediated Acquired EGFR-TKI Resistance in NSCLC: Mechanisms and Strategies

Frontiers in Oncology, 2019
Acquired resistance inevitably limits the curative effects of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), which represent the classical paradigm of molecular-targeted therapies in non-small-cell lung cancer (NSCLC).
Xuan Zhu, Lijie Chen, Ling Liu, Xing Niu
semanticscholar   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

Nature, 2021
M. Casanova-Acebes, Erica Dalla, A. Leader, J. LeBérichel, Jovan Nikolic, Blanca M. Morales, Markus Brown, Christie Chang, Leanna Troncoso, Steven T. Chen, A. Sastre-Perona, Matthew D. Park, Alexandra Tabachnikova, Maxime Dhainaut, Pauline Hamon, B. Maier, Catherine M. Sawai, Esperanza Agulló-Pascual, M. Schober, Brian D. Brown, B. Reizis, T. Marron, E. Kenigsberg, C. Moussion, P. Benaroch, J. Aguirre-Ghiso, M. Merad   +26 more
semanticscholar   +1 more source

Integrin αvβ6‐Targeted PET/CT Imaging of Non‐Small Cell Lung Cancer with [68Ga]Ga‐Trivehexin: Improved Preoperative Lymph Node Staging and Association with Immunohistochemistry

Advanced Science, EarlyView.
Integrin αvβ6‐targeted [68Ga]Ga‐Trivehexin positron emission tomography/computed tomography (PET/CT) can accurately identify regional lymph nodes and cerebral metastases in non‐small cell lung cancer (NSCLC) compared with 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG).
Huiqin Wu, Chongjiao Li, Ling Li, Yueli Tian, Zhiwei Xiao, Yiwei Huang, Juan Zhong, Jianying Huang, Qiongrong Chen, Yong He   +9 more
wiley   +1 more source

Total Lymphocyte Count, Neutrophil-Lymphocyte Ratio, and Platelet-Lymphocyte Ratio as Prognostic Factors in Advanced Non-Small Cell Lung Cancer with Chemoradiotherapy [Corrigenudm]

Cancer Management and Research, 2021
Song X, Chen D, Yuan M, Wang H, Wang Z. Cancer Manag. 2018;10:6677– 6683On page 6677, Abstract, Results subheading, the median baseline PLR should be 136.1.On page 6680, Results section, 2nd paragraph, the median baseline PLR should ...
Song X, Chen D, Yuan M, Wang H, Wang Z
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