Results 111 to 120 of about 286,663 (309)

IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF

, 2011
Background\ud \ud IL-20 is a pleiotrophic member of the IL-10 family and plays a role in skin biology and the development of haematopoietic cells. Recently, IL-20 has been demonstrated to have potential anti-angiogenic effects in non-small cell lung ...
Gray , Steven G., Kenneth J. O’Byrne, Anne-Marie Baird, Baird, Anne-Marie, O'Byrne, Kenneth J., Steven G. Gray   +5 more
core   +1 more source

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source

Practical management of NSCLC patients with long-term bevacizumab treatment: a report of four cases

, 2013
GJM Herder,1 H Codrington,2 CD Colder,3 JG Aerts4,51St Antonius Hospital, Nieuwegein, The Netherlands; 2Haga Hospital, The Hague, The Netherlands; 3St Jansdal Hospital, Harderwijk, The Netherlands; 4Amphia Hospital, Breda; 5Erasmus MC Rotterdam, The ...
Aerts JG, Colder CD, Codrington H, Herder GJM   +3 more
core  

CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation

, 2017
Background: Epidermal growth factor receptor (EGFR) inhibitors show favorable clinical response in some patients with non-small cell lung cancer (NSCLC) who have no EGFR mutation, indicating alternative mechanisms for their tumoricidal effects.
余忠仁;陳昆鋒, Wang, Cheng-Yi;Chao, Ting-Ting;Chang, Fang-Yu;Chen, Yen-Lin;Tsai, Yi-Ting;Lin, Hen-I;Huang, Yuh-Chin T.;Shiau, Chung-Wai;Yu, Chong-Jen;Chen, Kuen-Feng   +1 more
core   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Long Non-Coding RNA SNHG14 Regulates SPIN1 Expression to Accelerate Tumor Progression in Non-Small Cell Lung Cancer by Sponging miR-382-5p

Cancer Management and Research, 2020
Xiaoliang Chen, Pingan Song, Yuan Yao, Yang Yang Department of Thoracic Surgery, Gansu Gem Flower Hospital, Lanzhou 730060, Gansu, People’s Republic of ChinaCorrespondence: Xiaoliang Chen Department of Thoracic SurgeryGansu Gem Flower Hospital, 733
Chen X, Song P, Yao Y, Yang Y
doaj  

Tumor bed evaluation in non-small cell lung cancer of patients treated with different neoadjuvant strategies: morphometric analysis of stromal component.

, 2023
reservedBackground: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Diverse treatment approaches are accessible, and neoadjuvant therapy holds potential to enhance survival rates and elevate curative ...
BUFFON, LAURA
core  

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

Knockdown of circPRKCA Restrained Cell Growth, Migration, and Invasion of NSCLC Cells Both in vitro and in vivo via Regulating miR-330-5p/PDK1/AKT Pathway

Cancer Management and Research, 2020
Lanxiang Bai1 ,* Xiaonu Peng2 ,* Ruimei Sun3 1Disinfection Supply Center, Yantai Yuhuangding Hospital, Yantai 264000, Shandong, People’s Republic of China; 2Department of Thoracic Surgery, Yantai Yuhuangding Hospital, Yantai 264000, Shandong ...
Bai L, Peng X, Sun R
doaj  

Mutation prevalence in NCT00890825 NSCLC patients using MALDI-TOF panel compared to COSMIC NSCLC database.

, 2014
Mutation prevalence in NCT00890825 NSCLC patients using MALDI-TOF panel compared to COSMIC NSCLC database.
Jill Walker (582088), Susanne Müller (3174357), James L. Sherwood (582085), Marianne J. Ratcliffe (582087), Maria C. M. Orr (582086)   +4 more
core   +1 more source