Results 121 to 130 of about 260,886 (316)

Long Non-Coding RNA SNHG14 Regulates SPIN1 Expression to Accelerate Tumor Progression in Non-Small Cell Lung Cancer by Sponging miR-382-5p

Cancer Management and Research, 2020
Xiaoliang Chen, Pingan Song, Yuan Yao, Yang Yang Department of Thoracic Surgery, Gansu Gem Flower Hospital, Lanzhou 730060, Gansu, People’s Republic of ChinaCorrespondence: Xiaoliang Chen Department of Thoracic SurgeryGansu Gem Flower Hospital, 733
Chen X, Song P, Yao Y, Yang Y
doaj  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Knockdown of circPRKCA Restrained Cell Growth, Migration, and Invasion of NSCLC Cells Both in vitro and in vivo via Regulating miR-330-5p/PDK1/AKT Pathway

Cancer Management and Research, 2020
Lanxiang Bai1 ,* Xiaonu Peng2 ,* Ruimei Sun3 1Disinfection Supply Center, Yantai Yuhuangding Hospital, Yantai 264000, Shandong, People’s Republic of China; 2Department of Thoracic Surgery, Yantai Yuhuangding Hospital, Yantai 264000, Shandong ...
Bai L, Peng X, Sun R
doaj  

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Saferty and feasibility of surgical treatment of advanced stage NSCLC after targeted therapy or immunotherapy

openBackground I nuovi farmaci a bersaglio molecolare (Tyrosine Kinase Inhibitors, TKI) e immunoterapici (Immune Checkpoint Inhibitors, ICI) hanno dimostrato una buona efficacia nel trattamento del NSCLC in stadio avanzato non resecabile.
VOLPATO, ANNA
core  

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Heterojunction‐Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases

Advanced Science, EarlyView.
Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen, Chaoqi Wang, Xi Yu, Yuming Jiang, Yijiao Qu, Huihui Fu, Yuyin Bu, Xiaoyong Zhang, Zongxiu Nie   +8 more
wiley   +1 more source

Long Noncoding RNA LINC01426 Sequesters microRNA-519d-5p to Promote Non-Small Cell Lung Cancer Progression by Increasing ETS1 Expression

Cancer Management and Research, 2020
Jixin Dai,1 Bing Wang,2 Yueming Zhao,1 Xuerong Zuo,1 Hongxia Cui,1 Xi Chen,2 Xianhong Liu1 1Department of Oncology, Jilin Cancer Hospital, Changchun, Jilin 130000, People’s Republic of China; 2Department of Radiotherapy, Jilin Cancer Hospital ...
Dai J, Wang B, Zhao Y, Zuo X, Cui H, Chen X, Liu X   +6 more
doaj  

NRG1 Fusions in NSCLC: Being eNRGy Conscious

Brinda Gupta, Laura Gosa Barrett, Stephen V Liu Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USACorrespondence: Stephen V Liu, Georgetown University, Lombardi Comprehensive Cancer Center, 3800 Reservoir Road NW, Washington,
Gupta B, Liu SV, Gosa Barrett L
core  

Tests for detection of ROS1 gene alterations in people with non-small cell lung cancer (NSCLC): A Health Technology Assessment.

, 2021
Key messages: The Norwegian Institute of Public Health has been commissioned to evaluate molecular tests for the identification of somatic ROS1 gene alterations in people with locally advanced or metastatic non-small cell lung cancer (NSCLC). People with
Hamidi Ashtiani, Vida, Flodgren, Gerd Monika   +1 more
core