Results 91 to 100 of about 278,336 (309)

AI‐Powered Framework for Evaluating Drug Efficacy for Three‐Dimensional In Vitro Cancer Models in Robot‐Assisted Production

Advanced Robotics Research, EarlyView.
An AI‐powered, robot‐assisted framework automatically produces, images, and analyzes 3D tumor spheroids to evaluate drug efficacy. Integrated modules handle spheroid formation, live/dead staining, brightfield imaging, and automated image analysis, including spheroid segmentation, viability and metrics to assess the drug treatment efficacy. The workflow
Dalia Mahdy, Jesus Nieves, Lukas Königer, Matthias Peindl, Fabio Erhard, Marc Möllmann, Anke Klingner, Markus Münig, Bibin Babu, Thomas Schwarz, Marco Metzger, Gudrun Dandekar, Maximiliane Wußmann, Jan Hansmann   +13 more
wiley   +1 more source

Efficacy and Safety Aiming at the Combined-Modality Therapy of External Beam Radiotherapy (40Gy) and Iodine-125 Seed Implantation for Locally Advanced NSCLC in the Elderly

Cancer Management and Research, 2021
Li-Jun Tian,1,* Hong-Zhi Liu,2,* Qiang Zhang,1 Dian-Zhong Geng,1 Yu-Qing Huo,1 Shou-Jian Xu,1 Yan-Zhang Hao1 1Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong, People’s Republic of China; 2Department of Orthopedics ...
Tian LJ, Liu HZ, Zhang Q, Geng DZ, Huo YQ, Xu SJ, Hao Y   +6 more
doaj  

Liquid Biopsy in Non-Small Cell Lung Cancer (NSCLC) [PDF]

, 2017
Lung cancer is the leading cause of cancer deaths worldwide. To date, the gold standard for the molecular analysis of a patient affected by NSCLC is the tissue biopsy.
Sober, L., Pablo Reclusa, Pauwels, P., CASTIGLIA, Marta, Antonio Russo, Rolfo, CHRISTIAN DIEGO, Reclusa, P., Alessandro Perez, RUSSO, Antonio, Patrick Pauwels, Christian Rolfo, Marta Castiglia, Francesco Passiglia, Perez, Alessandro, Laure Sober, PASSIGLIA, Francesco   +15 more
core   +1 more source

Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia

, 2022
Background: Although first- and second-generation EGFR TKIs are considered first-line treatment in EGFRm+ NSCLC, most patients develop resistance and progress, commonly, EGFR T790M mutation.
Yong, Kek Pang, Sing, Yang Soon, Zainal Abidin, Muhammad 'Adil, Lye, Mun Tho, Chong, Kin Liam, Muhamad Nor, Ibtisam, Mau, Ern Poh, Samsudin, Azlina, How, Soon Hin, Sin, Nee Tan, Hasbullah, Harissa H, Kean, Fatt Ho, Choo, Khoon Ong, Omar, Azza, Gwo, Fuang Ho, Thiagarajan, Muthukkumaran, Ariffin, Roziana   +16 more
core   +1 more source

EpCAM+ Extracellular Vesicle PD‐L1 Dynamics as a Predictive Biomarker of Immune Checkpoint Blockade Response

Advanced Science, EarlyView.
A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun, Jinyoung Kim, Chang Gon Kim, Seokhyeong Go, Mina Han, Yujin Ouck, Soojin Jang, Seong Uk Son, Gamin Kim, Wonrak Son, Eunjung Kim, Min Hee Hong, Ja Hyun Yeo, Eun‐Kyung Lim, Hye Ryun Kim, Seungjoo Haam   +15 more
wiley   +1 more source

Knockdown of Long Non-Coding RNA HOTAIR Suppresses Cisplatin Resistance, Cell Proliferation, Migration and Invasion of DDP-Resistant NSCLC Cells by Targeting miR-149-5p/Doublecortin-Like Kinase 1 Axis

Cancer Management and Research, 2020
Yiyi Zhan, Kahaerjiang Abuduwaili, Xiuli Wang, Yanli Shen, Saiteer Nuerlan, Chunling Liu The Second Department of Pulmonary Medicine, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s ...
Zhan Y, Abuduwaili K, Wang X, Shen Y, Nuerlan S, Liu C   +5 more
doaj  

The Clinical Value of Computed Tomography (CT)-Guided 125I Brachytherapy for Locally Advanced Non-Small Cell Lung Cancer After Progression of Concurrent Radiochemotherapy

Cancer Management and Research, 2021
Zhanwang Xiang,1,* Zhihui Zhong,2,* Luwen Mu,1 Guohong Li,3 Churen Zhou,1 Haofan Wang,1 Mingsheng Huang1 1Interventional Radiology Program, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, People’s Republic of China ...
Xiang Z, Zhong Z, Mu L, Li G, Zhou C, Wang H, Huang M   +6 more
doaj  

NRG1 Fusions in NSCLC: Being eNRGy Conscious [PDF]

Brinda Gupta, Laura Gosa Barrett, Stephen V Liu Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USACorrespondence: Stephen V Liu, Georgetown University, Lombardi Comprehensive Cancer Center, 3800 Reservoir Road NW, Washington,
Gupta B, Liu SV, Gosa Barrett L
core  

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source