Results 91 to 100 of about 260,886 (316)

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Efficacy and Safety Aiming at the Combined-Modality Therapy of External Beam Radiotherapy (40Gy) and Iodine-125 Seed Implantation for Locally Advanced NSCLC in the Elderly

Cancer Management and Research, 2021
Li-Jun Tian,1,* Hong-Zhi Liu,2,* Qiang Zhang,1 Dian-Zhong Geng,1 Yu-Qing Huo,1 Shou-Jian Xu,1 Yan-Zhang Hao1 1Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong, People’s Republic of China; 2Department of Orthopedics ...
Tian LJ, Liu HZ, Zhang Q, Geng DZ, Huo YQ, Xu SJ, Hao Y   +6 more
doaj  

Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib

, 2015
Martin Reck,1 Anders Mellemgaard2 1Department of Thoracic Oncology, Lung Clinic Grosshansdorf, and member of the Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany; 2Department of Oncology, Herlev University Hospital ...
Mellemgaard A, Reck M, Reck, Martin, Mellemgaard, Anders   +3 more
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Knockdown of Long Non-Coding RNA HOTAIR Suppresses Cisplatin Resistance, Cell Proliferation, Migration and Invasion of DDP-Resistant NSCLC Cells by Targeting miR-149-5p/Doublecortin-Like Kinase 1 Axis

Cancer Management and Research, 2020
Yiyi Zhan, Kahaerjiang Abuduwaili, Xiuli Wang, Yanli Shen, Saiteer Nuerlan, Chunling Liu The Second Department of Pulmonary Medicine, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s ...
Zhan Y, Abuduwaili K, Wang X, Shen Y, Nuerlan S, Liu C   +5 more
doaj  

The Clinical Value of Computed Tomography (CT)-Guided 125I Brachytherapy for Locally Advanced Non-Small Cell Lung Cancer After Progression of Concurrent Radiochemotherapy

Cancer Management and Research, 2021
Zhanwang Xiang,1,* Zhihui Zhong,2,* Luwen Mu,1 Guohong Li,3 Churen Zhou,1 Haofan Wang,1 Mingsheng Huang1 1Interventional Radiology Program, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, People’s Republic of China ...
Xiang Z, Zhong Z, Mu L, Li G, Zhou C, Wang H, Huang M   +6 more
doaj  

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Clinical impact of molecular characterization on liquid biopsy in patients with advanced NSCLC

, 2022
reservedPresupposti dello studio: il trattamento delle neoplasie polmonari in stadio avanzato è stato rivoluzionato dall’avvento delle terapie a bersaglio molecolare e dell’immunoterapia.
ALAM, M ASHRAFUL
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

[Role of HER2 in NSCLC].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2015
The therapeutic strategy of non-small cell lung cancer (NSCLC) is dramatically changed with the introduction of molecular targeted drugs in the last years, resulting in a series of results in histologic and molecular level. The discovery of epidermal growth factor receptor (EGFR) mutation, Kirsten rat sarcoma (KRAS) viral oncogene mutation and ...
Kun ZHANG, Hong WANG
openaire   +2 more sources