Results 31 to 40 of about 355,709 (346)

GPX2 and BMP4 as Significant Molecular Alterations in The Lung Adenocarcinoma Progression: Integrated Bioinformatics Analysis [PDF]

Cell Journal, 2022
Objective: Non-small cell lung adenocarcinoma (NSCLC) is the most common type of lung cancer, which is considered as the most lethal and prevalent cancer worldwide. Recently, molecular changes have been implicated to play a significant role in the cancer
Mohammad Hossein Derakhshan Nazari, Rana Askari Dastjerdi, Parnian Ghaedi Talkhouncheh, Ahmad Bereimipour, Hamidreza Mollasalehi, Amir Ali Mahshad, Ali Razi, Mohammad Hossein Nazari, Amin Ebrahimi Sadrabadi, Sara Taleahmad   +9 more
doaj   +1 more source

Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC

New England Journal of Medicine, 2018
BACKGROUND An earlier analysis in this phase 3 trial showed that durvalumab significantly prolonged progression‐free survival, as compared with placebo, among patients with stage III, unresectable non–small‐cell lung cancer (NSCLC) who did not have ...
S. Antonia, A. Villegas, D. Daniel, D. Vicente, S. Murakami, R. Hui, T. Kurata, A. Chiappori, K. Lee, M. de Wit, B. Cho, M. Bourhaba, X. Quantin, T. Tokito, T. Mekhail, D. Planchard, Young‐Chul Kim, C. Karapetis, S. Hiret, G. Ostoros, K. Kubota, J. Gray, L. Paz-Ares, J. de Castro Carpeño, C. Faivre-Finn, M. Reck, J. Vansteenkiste, D. Spigel, C. Wadsworth, G. Melillo, Maria Taboada, P. Dennis, M. Özgüroğlu   +32 more
semanticscholar   +1 more source

Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Molecular Cancer, 2021
CD8+ T cells play a critical role in the innate antitumour immune response. Recently, CD8+ T cell dysfunction has been verified in various malignant cancers, including non-small cell lung cancer (NSCLC).
Shi-wei Chen, Shu-Qiang Zhu, Xu Pei, Bai-Quan Qiu, Dian Xiong, Xiang Long, Kun Lin, Feng Lu, Jianjun Xu, Yongbing Wu   +9 more
semanticscholar   +1 more source

Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2

Theranostics, 2021
Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA damage drugs. However, the mechanisms behind this resistance are still unclear.
Dongliang Wang, Chaoshuai Zhao, Fei Xu, Aimi Zhang, Mingming Jin, Kunchi Zhang, Liu Liu, Qian Hua, Jian Zhao, Jianju Liu, Hao Yang, Gang Huang   +11 more
semanticscholar   +1 more source

Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC.

New England Journal of Medicine, 2019
BACKGROUND Osimertinib is a third-generation, irreversible tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR-TKI) that selectively inhibits both EGFR-TKI-sensitizing and EGFR T790M resistance mutations.
S. Ramalingam, J. Vansteenkiste, D. Planchard, B. Cho, J. Gray, Y. Ohe, Caicun Zhou, T. Reungwetwattana, Ying Cheng, B. Chewaskulyong, R. Shah, M. Cobo, K. Lee, P. Cheema, M. Tiseo, T. John, Meng-Chih Lin, F. Imamura, T. Kurata, A. Todd, R. Hodge, M. Saggese, Y. Rukazenkov, J. Soria   +23 more
semanticscholar   +1 more source

Targeting the PI3K/Akt/mTOR pathway in non‐small cell lung cancer (NSCLC)

Thoracic Cancer, 2020
The traditional classification of lung cancer into small cell lung cancer and non‐small cell lung cancer (NSCLC) has been transformed with the increased understanding of the molecular alterations and genomic biomarkers that drive the development of lung ...
A. Tan
semanticscholar   +1 more source

The Landscape of Immunotherapy Resistance in NSCLC

Frontiers in Oncology, 2022
Lung cancer is the leading cause of cancer mortality worldwide. Immunotherapy has demonstrated clinically significant benefit for non-small-cell lung cancer, but innate (primary) or acquired resistance remains a challenge. Criteria for a uniform clinical definition of acquired resistance have been recently proposed in order to harmonize the design of ...
Daniele Frisone, Alex Friedlaender, Alex Friedlaender, Alfredo Addeo, Alfredo Addeo, Petros Tsantoulis, Petros Tsantoulis   +6 more
openaire   +3 more sources

[Role of HER2 in NSCLC].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2015
The therapeutic strategy of non-small cell lung cancer (NSCLC) is dramatically changed with the introduction of molecular targeted drugs in the last years, resulting in a series of results in histologic and molecular level. The discovery of epidermal growth factor receptor (EGFR) mutation, Kirsten rat sarcoma (KRAS) viral oncogene mutation and ...
Kun Zhang, Hong Wang
openaire   +3 more sources

Ferroptosis-associated gene SLC7A11 is upregulated in NSCLC and correlated with patient’s poor prognosis: An integrated bioinformatics analysis

Pteridines, 2021
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, which was involved in the progression of malignant tumors including non-small cell lung cancer (NSCLC).
Huang He, Liu Juan, Wu Haiyan, Liu Fang, Zhou Xiaoxi   +4 more
doaj   +1 more source

Updated Prognostic Factors in Localized NSCLC

Cancers, 2022
Simple Summary In resected lung cancer, adjuvant and neoadjuvant chemotherapy following surgery are currently mainly based on TNM classification. With the validation and ongoing trials of targeted therapies in this situation, the relapse risk evaluation ...
S. Garinet, Pascal Wang, A. Mansuet-Lupo, L. Fournel, M. Wislez, H. Blons   +5 more
semanticscholar   +1 more source