Results 81 to 90 of about 355,709 (346)

CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer

OncoImmunology, 2017
CD39/CD73-adenosine pathway has been recently defined as an important tumor-induced immunosuppressive mechanism. We here documented a fraction of CD11b+CD33+ myeloid-derived suppressor cells (MDSCs) in peripheral blood and tumor tissues from non-small ...
Jieyao Li, Liping Wang, Xinfeng Chen, Lifeng Li, Yu Li, Yu Ping, Lan Huang, Dongli Yue, Zhen Zhang, Fei Wang, Feng Li, Li Yang, Jianmin Huang, Shuangning Yang, Hong Li, Xuan Zhao, Wenjie Dong, Yan Yan, Song Zhao, Bo Huang, Bin Zhang, Yi Zhang   +21 more
doaj   +1 more source

SChLAP1 contributes to non-small cell lung cancer cell progression and immune evasion through regulating the AUF1/PD-L1 axis

Autoimmunity, 2021
SChLAP1 is recently reported as a key oncogenic long non-coding RNA in human cancer. However, whether SChLAP1 functions in non-small cell lung cancer (NSCLC) and its specific potential regulatory mechanism remain unexplored.
Zhonghai Du, Shuxian Niu, Juan Wang, Jun Wu, Sheng Li, Xiuxiu Yi   +5 more
doaj   +1 more source

The mechanism of m6A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by β-elemene

Cell Death and Disease, 2020
N6-methyladenosine (m6A) modification can alter gene expression by regulating RNA splicing, stability, translocation, and translation. Emerging evidence shows that m6A modification plays an important role in cancer development and progression, including ...
Shuiping Liu, Qiujie Li, Guohua Li, Qin Zhang, Lvjia Zhuo, Xuemeng Han, Mingming Zhang, Xiaying Chen, Ting Pan, Lili Yan, Ting Jin, Jianjun Wang, Qun Lv, Xinbing Sui, Tian Xie   +14 more
semanticscholar   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Expression analysis of MINA53: correlation with aberrantly expressed mRNAs and pathological features in non-small lung cancer

Biotechnology & Biotechnological Equipment, 2021
The present study investigated the expression signature of the MINA53 gene in 50 lung adenocarcinoma (LUAD) and 50 squamous cell lung carcinoma (LUSC) tumors and their adjacent non-tumor tissues via RT-qPCR.
Veronika Petkova, Dora Marinova, Silva Kyurkchiyan, Gergana Stancheva, Evgeni Mekov, Darina Kachakova-Yordanova, Yanina Slavova, Dimitar Kostadinov, Vanyo Mitev, Radka Kaneva   +9 more
doaj   +1 more source

The relationship between PD-L1 expression and tumor driver gene mutations and survival in non small cell lung carcinoma

Polish Journal of Pathology, 2022
To explore the relationship between PD-L1 expression and gene mutations and survival. PD L1, ALK and MET protein expression were detected by immunohistochemistry, and EGFR gene mutation by RT-PCR in 209 cases of NSCLC.
Kin Chan, Hong Vong, Wai Chu, Kun Cheng, Xue Zhong, Jian Wen   +5 more
doaj   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

CircRNA_101237 promotes NSCLC progression via the miRNA-490-3p/MAPK1 axis

Scientific Reports, 2020
Non-small cell lung cancer (NSCLC) is a common type of lung cancer, characterized by a poor prognosis. In the last several years, more and more studies have demonstrated the significant roles played by circular RNAs (circRNAs) in different human tumors ...
Zhi-ye Zhang, Xiao-hui Gao, Ming Ma, Chun-ling Zhao, Ya-li Zhang, Shuang-shuang Guo   +5 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Knockdown of Long Non-Coding RNA HOTAIR Suppresses Cisplatin Resistance, Cell Proliferation, Migration and Invasion of DDP-Resistant NSCLC Cells by Targeting miR-149-5p/Doublecortin-Like Kinase 1 Axis

Cancer Management and Research, 2020
Yiyi Zhan, Kahaerjiang Abuduwaili, Xiuli Wang, Yanli Shen, Saiteer Nuerlan, Chunling Liu The Second Department of Pulmonary Medicine, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People’s ...
Zhan Y, Abuduwaili K, Wang X, Shen Y, Nuerlan S, Liu C   +5 more
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