AAV1.NT-3 gene therapy prevents age-related sarcopenia. [PDF]
Aging (Albany NY), 2023 Sarcopenia is progressive loss of muscle mass and strength, occurring during normal aging with significant consequences on the quality of life for elderly. Neurotrophin 3 (NT-3) is an important autocrine factor supporting Schwann cell survival and differentiation and stimulating axon regeneration and myelination.
Ozes B +5 more
europepmc +4 more sources
AAV1.NT-3 gene therapy for X-linked Charcot-Marie-Tooth neuropathy type 1. [PDF]
Gene Ther, 2022 X-linked Charcot-Marie-Tooth neuropathy (CMTX) is caused by mutations in the gene encoding Gap Junction Protein Beta-1 (GJB1)/Connexin32 (Cx32) in Schwann cells.
Ozes B +10 more
europepmc +4 more sources
Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]
Tissue Eng Part A, 2020 One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Smith DR +8 more
europepmc +5 more sources
Haloperidol’s Effect on the Expressions of TGFB, NT-3, and BDNF genes in Cultured Rat Microglia [PDF]
Basic and Clinical Neuroscience, 2020 Introduction: Microglia, small glial cells, i.e. mesodermal in origin and found in the brain and spinal cord, play a key role in the maintenance of neurons and immune defense. Haloperidol, an antipsychotic drug, is used to treat numerous neurological and
Elham Namjoo +6 more
doaj +4 more sources
AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy. [PDF]
Gene Ther, 2018 The synapse between inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs) has been identified as a sensitive structure to noise-induced damage in the mammalian cochlea. Since this synapse provides the major information pathway from the cochlea to the auditory brain, it is important to maintain its integrity.
Chen H +5 more
europepmc +5 more sources
BDNF/NT-3 Growth Factors Receptor [PDF]
Definitions, 2020 National Cancer Institute
semanticscholar +3 more sources
AAV1.NT-3 gene therapy attenuates spontaneous autoimmune peripheral polyneuropathy. [PDF]
Gene Ther, 2016 The spontaneous autoimmune peripheral polyneuropathy (SAPP) model in B7-2 knockout non-obese diabetic mice shares clinical and histological features with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Secondary axonal loss is prominent in the progressive phase of this neuropathy. Neurotrophin 3 (NT-3) is an important autocrine factor
Yalvac ME +5 more
europepmc +5 more sources
AAV1.NT-3 gene therapy for charcot-marie-tooth neuropathy. [PDF]
Mol Ther, 2014 Charcot-Marie-Tooth (CMT) neuropathies represent a heterogeneous group of peripheral nerve disorders affecting 1 in 2,500 persons. One variant, CMT1A, is a primary Schwann cell (SC) disorder, and represents the single most common variant. In previous studies, we showed that neurotrophin-3 (NT-3) improved the trembler(J) (Tr(J)) mouse and also showed ...
Sahenk Z +9 more
europepmc +4 more sources
Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process [PDF]
Frontiers in Neuroscience, 2023 The dentate gyrus (DG) of the hippocampus regulates stress-related emotional behaviors and ensures neurogenesis throughout life. Neurotrophin-3 (NT-3) is a neurotrophic factor that regulates neuronal differentiation, survival, and synaptic formation in ...
Nanami Kasakura +6 more
doaj +2 more sources
Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice. [PDF]
Nat Commun, 2019 Locomotor function, mediated by lumbar neural circuitry, is modulated by descending spinal pathways. Spinal cord injury (SCI) interrupts descending projections and denervates lumbar motor neurons (MNs).
Han Q +12 more
europepmc +2 more sources