Results 121 to 130 of about 17,130,313 (339)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Biosynthesis of Bioactive Human Neurotrophic Factor 3 in Silkworms and Its Biomedical Applications

Insects
Neurotrophic factor 3 (NT-3), a potent neurotrophin, promotes neuronal survival and axonal regeneration while demonstrating a unique capacity to induce lineage-specific differentiation of pluripotent stem cells into functional neurons, underscoring its ...
Wenjing Geng, Liang Lu, Tangmin Li, Mingyi Zhou, Wei Chen, Hao Tan, Debin Zhong, Guanwang Shen, Ping Lin, Qingyou Xia, Ping Zhao, Zhiqing Li   +11 more
doaj   +1 more source

Expression of Placental Neurotrophin-3 (NT-3) in Physiological Pregnancy, preeclampsia and chorioamnionitis

Clinical Medicine Insights: Pathology, 2009
Neurotrophic factors are a group of proteins that act as paracrine and autocrine growth factors. They are involved in the regulation of morphogenesis and development of several tissues.
Alessandra Casciaro, Felice Arcuri, Rossella Occhini, M. Stefania Toti, Claudio De Felice, Paolo Toti   +5 more
doaj   +1 more source

Postsynaptic Secretion of BDNF and NT-3 from Hippocampal Neurons Depends on Calcium–Calmodulin Kinase II Signaling and Proceeds via Delayed Fusion Pore Opening

Journal of Neuroscience, 2007
The mammalian neurotrophins (NTs) NGF, BDNF, NT-3, and NT-4 constitute a family of secreted neuronal growth factors. In addition, NTs are implicated in several forms of activity-dependent synaptic plasticity.
Richard Kolarow, T. Brigadski, V. Lessmann   +2 more
semanticscholar   +1 more source

Multilayer parking with screening on a random tree [PDF]

, 2009
In this paper we present a multilayer particle deposition model on a random tree. We derive the time dependent densities of the first and second layer analytically and show that in all trees the limiting density of the first layer exceeds the density in ...
A. Sudbury, C. Külske, H.G. Dehling, P. Meakin, R. Gouet, S. R. Fleurke, S.R. Fleurke, T.M. Liggett   +7 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia

Neurobiology of Disease, 2009
Altered neurodevelopment and plasticity are implicated in schizophrenia pathology. Based on the important role of neurotrophic factors in brain development and plasticity as well as their extensive expression in hippocampal areas, we hypothesized that a ...
Mona K. Otnæss, Srdjan Djurovic, Lars M. Rimol, Bettina Kulle, Anna K. Kähler, Erik G. Jönsson, Ingrid Agartz, Kjetil Sundet, Håkan Hall, Sally Timm, Thomas Hansen, Joseph H. Callicott, Ingrid Melle, Thomas Werge, Ole A. Andreassen   +14 more
doaj   +1 more source

Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival [PDF]

, 1991
We have demonstrated that the extensive degeneration of motoneurons in the rat facial nucleus after transection of the facial nerve in newborn rats can be prevented by local ciliary neurotrophic factor (CNTF) administration.
Arakawa, Yoshihiro, Kreutzberg, Georg W., Sendtner, Michael, Stöckli, Kurt A., Thoenen, Hans   +4 more
core  

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Serum 3-Nitrotyrosine in the Cardiovascular Disease of Patients with Systemic Lupus Erythematosus

Antioxidants
3-Nitrotyrosine (3-NT) is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. It serves as an indicator of inflammation, cell damage, and nitric oxide production.
Juan C. Quevedo-Abeledo, Marta Hernández-Díaz, María García-González, Fuensanta Gómez-Bernal, Cristina Almeida-Santiago, Elena Heras-Recuero, Antonia de Vera-González, Alejandra González-Delgado, Pedro Abreu-González, Beatriz Tejera-Segura, Candelaria Martín-González, Miguel Á. González-Gay, Iván Ferraz-Amaro   +12 more
doaj   +1 more source