Effects of Vitamin D3 in Long-Term Ovariectomized Rats Subjected to Chronic Unpredictable Mild Stress: BDNF, NT-3, and NT-4 Implications. [PDF]
Nutrients, 2019 The purpose of this study was to explore the antidepressant-like effects of vitamin D3 at different doses (1.0, 2.5, and 5.0 mg/kg sc) on a model of depression produced by chronic unpredictable mild stress (CUMS) for 28 days in long-term (3 months ...
Koshkina A +4 more
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Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury. [PDF]
Int J Mol Sci, 2017 Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and neurotransmitter release, and elicit the plasticity and growth of axons within the adult central and peripheral nervous system.
Keefe KM, Sheikh IS, Smith GM.
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Transient and persistent expression of NT-3/HDNF mRNA in the rat brain during postnatal development [PDF]
Journal of Neuroscience, 1991 Neurotrophin-3 (NT-3) is closely related to two known neurotrophic agents, NGF and brain-derived neurotrophic factor (BDNF), and acts upon overlapping, yet distinct, populations of peripheral ganglia.
WJ Friedman +2 more
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Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles [PDF]
Cells, 2020 Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that they are endowed with different types of myogenic cells, all of which present an outstanding regenerative potential. Neurotrophins are
Génova Carrero-Rojas +3 more
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Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation [PDF]
Molecular Brain, 2011 BackgroundNeurotrophins elicit both acute and long-term modulation of synaptic transmission and plasticity. Previously, we demonstrated that the long-term synaptic modulation requires the endocytosis of neurotrophin-receptor complex, the activation of ...
H. Je +8 more
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Long-term production of BDNF and NT-3 induced by A91-immunization after spinal cord injury. [PDF]
BMC Neurosci, 2016 Background After spinal cord (SC)-injury, a non-modulated immune response contributes to the damage of neural tissue. Protective autoimmunity (PA) is a T cell mediated, neuroprotective response induced after SC-injury.
Martiñón S +7 more
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Artificial Cells, Nanomedicine, and Biotechnology, 2020 Microvascular disturbance, excessive inflammation and gliosis are key pathophysiologic changes in relation to functional status following the traumatic spinal cord injury (SCI).
Zi-Xing Xu +4 more
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TrkA Receptor “Hot Spots” for Binding of NT-3 as a Heterologous Ligand [PDF]
Journal of Biological Chemistry, 2007 Neurotrophins signal via Trk tyrosine kinase receptors. Nerve growth factor (NGF) is the cognate ligand for TrkA, the brain-derived neurotrophic factor for TrkB, and NT-3 for TrkC. NT-3 also binds TrkA as a lower affinity heterologous ligand.
Ljubica Ivanisevic +4 more
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Role of endogenous NT-3 in neuronal activity and neurogenesis in the hippocampal dentate gyrus
Neuroscience ResearchNeurotrophin-3 (NT-3) is a neurotrophic factor that regulates neuronal differentiation and synaptic plasticity. In the adult central nervous system, NT-3 is predominantly expressed in the hippocampal dentate gyrus (DG).
Nanami Kasakura +3 more
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A chemoattractant role for NT-3 in proprioceptive axon guidance. [PDF]
PLoS Biology, 2004 Neurotrophin-3 (NT-3) is required for proprioceptive neuron survival. Deletion of the proapoptotic gene Bax in NT-3 knockout mice rescues these neurons and allows for examination of their axon growth in the absence of NT-3 signaling.
Bariş Genç +3 more
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