Results 21 to 30 of about 454,651 (246)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

VOC Gas Sensors Based on Zinc Stannate Nanoparticles Decorated with Silver

Nanomaterials
Today, air pollution is a global environmental problem. A huge amount of explosive and combustible gas emissions that negatively affect nature and human health. Gas sensors are one of the ways to prevent this impact.
Svetlana S. Nalimova, Zamir V. Shomakhov, Dmitry A. Kozodaev, Arina A. Rybina, Sergey S. Buzovkin, Cong D. Bui, Ivan A. Novikov, Vyacheslav A. Moshnikov   +7 more
doaj   +1 more source

Reflections on an evaluation of the ‘Remote Health Experience’ - an interprofessional learning, cultural immersion program

Rural and Remote Health, 2022
Introduction: Cultural immersion can be an effective method of health professional student cultural learning, and part of interprofessional learning.
Sue Lenthall, Leigh Moore, Madeleine Bower, Kylie Stothers, Greg Raymond, Chris Rissel   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

El trabajo: concepciones de jóvenes que laboran en Call Centers en una ciudad intermedia colombiana

Revista Latinoamericana en Ciencias Sociales, Niñez y Juventud, 2017
Las organizaciones actuales han desarrollado nuevos modelos para almacenar, transferir y transformar la información; esta era se caracteriza por su alta demanda de las nuevas tecnologías y de las características del ...
Mariana Castaño-Ravagli, Claudia Milena Álvarez-Giraldo   +1 more
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Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Metamorphopsia with SMART Syndrome: A Case Report

Case Reports in Neurology
Introduction: SMART syndrome is a rare complication of brain radiotherapy. This is the first described presentation of SMART syndrome with metamorphopsia, which responded to aspirin, verapamil, and high-dose L-arginine therapy.
Luke Flain, Aisha Lay, Eden Gadil, Karlie James, Sanchayan Thanancheyan, Stephen Bacchi, Rudy Goh   +6 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

The need for greater opioid pharmacovigilance in COPD

International Journal of COPD, 2017
Nicholas T Vozoris1–3 1Division of Respirology, Department of Medicine, St Michael’s Hospital, Toronto, ON, Canada; 2Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada; 3Department
Vozoris NT
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