Results 51 to 60 of about 2,559,807 (281)

Transition of pediatric patients with bronchiectasis to adult medical care in the Northern Territory: A retrospective chart audit

Frontiers in Pediatrics, 2023
BackgroundBronchiectasis is increasingly being recognized to exist in all settings with a high burden of disease seen in First Nations populations. With increasing numbers of pediatric patients with chronic illnesses surviving into adulthood, there is ...
Kobi L. Schutz, Kobi L. Schutz, Nicholas Fancourt, Anne B. Chang, Anne B. Chang, Peter Morris, Rachel Buckley, Edwina Biancardi, Kathryn Roberts, James Cush, Subash Heraganahally, Subash Heraganahally, Gabrielle B. McCallum   +12 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Natriuretic peptides and integrated risk assessment for cardiovascular disease. an individual-participant-data meta-analysis [PDF]

, 2016
BACKGROUND: Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable ...
Adam S, Butterworth, Andreas, Luchner, Angela M, Wood, Brendan, M. Everett, Børge G, Nordestgaard, Caroline, N. Kistorp, Christie M, Ballantyne, Christopher, Defilippi, Daniel F, Freitag, Daniel, Levy, Demosthenes, B. Panagiotakos, DI ANGELANTONIO, EMANUELE, Frank, Kee, Goya Wannamethee, S, James A, de Lemos, Jari A. Laukkanen, Maryam Kavousi, Jens, Rosenberg, Johan, Ärnlöv, John, Danesh, Jonas, Andersson, Jorge R, Kizer, Juan Pablo, Casas, Jukka, T. Salonen, Jussi, Kauhanen, Lars, Lind, Lisa, Pennells, Lori B, Daniels, Mary, Cushman, Michael, Hecht Olsen, Michael, Sweeting, Nancy, R. Cook, Naveed, Sattar, Olle, Melander, Oscar, H. Franco, Paul M, Ridker, Pei, Gao, Peter, Willeit, Rajiv, Chowdhury, RUBATTU, Speranza Donatella, Rudolf, A. de Boer, Sarah, A. Spackman, Simon G, Thompson, Stefan, Kiechl, Stella, Trompet, Stephen Kaptoge, Paul Welsh, Stephen, Burgess, Suzanne, Judd, Thomas, Mueller, Torben, Jørgensen, Toshiharu, Ninomiya, Veikko, Salomaa, Vijay, Nambi, Vilmundur, Gudnason, Wayne, D. Rosamond   +53 more
core   +1 more source

The need for greater opioid pharmacovigilance in COPD

International Journal of COPD, 2017
Nicholas T Vozoris1–3 1Division of Respirology, Department of Medicine, St Michael’s Hospital, Toronto, ON, Canada; 2Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada; 3Department
Vozoris NT
doaj  

Engaging Remote Aboriginal Communities in COVID-19 Public Health Messaging via Crowdsourcing

Frontiers in Public Health, 2022
Health comunication is a critical component of pandemic mitigation, but mainstream prevention messaging often lacks social, cultural and linguistic relevance to vulnerable populations.
Miriam Glennie, Michelle Dowden, Mark Grose, Meg Scolyer, Alessandra Superina, Karen Gardner   +5 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

ST2 in Stable and Unstable Ischemic Heart Diseases [PDF]

, 2015
Circulating suppression of tumorigenicity 2 (ST2) predicts cardiovascular outcomes and mortality in ischemic heart disease (IHD). ST2 does not correlate with traditional risk indicators as closely as N-terminal pro–brain natriuretic peptide (NT-proBNP ...
DI SOMMA, Salvatore, Mueller, T., Richards, Am   +2 more
core   +1 more source

Toward wafer-scale diamond nano- and quantum technologies

APL Materials, 2019
We investigate native nitrogen vacancy (NV) and silicon vacancy (SiV) color centers in a commercially available, heteroepitaxial, wafer-sized, mm thick, single-crystal diamond.
Richard Nelz, Johannes Görlitz, Dennis Herrmann, Abdallah Slablab, Michel Challier, Mariusz Radtke, Martin Fischer, Stefan Gsell, Matthias Schreck, Christoph Becher, Elke Neu   +10 more
doaj   +1 more source

Bilateral diffuse pulmonary infiltrates secondary to malignant peritoneal mesothelioma – A rare clinical presentation

Respiratory Medicine Case Reports, 2019
Diffuse pulmonary metastasis secondary to primary peritoneal malignant mesothelioma is rarely reported in the literature. In this report we describe a 59-year-old Caucasian women with no known previous asbestos exposure presenting with bilateral diffuse ...
Madeleine Haygarth, Kyi Kyi Zaw, Victoria Yachmenikova, Adrian M.J. Pokorny, Kin Keung Kwong, Subash S. Heraganahally   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source