Results 121 to 130 of about 3,868,782 (255)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Management, storage and disposal of nuclear and radioactive waste (Issues Paper Four)
, 2015 This Nuclear Fuel Cycle Royal Commission Issues Paper looks at the possibility of managing, storing and disposing of nuclear and radioactive waste in South Australia, and examines the risks and opportunities of doing ...
Nuclear Fuel Cycle Royal Commission
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Prospects for Nuclear Power [PDF]
The prospects for a revival of nuclear power were dim even before the partial reactor meltdowns at the Fukushima nuclear plant. Nuclear power has long been controversial because of concerns about nuclear accidents, proliferation risk, and the storage of ...
Lucas W. Davis
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 1978 Approximately 200 pagesThis is the third of a three-part Environmental Statement related to the proposed action described below. This Draft Statement is a Supplement to the Final Environmental Statement, Part II (NUREG-0056) issued in September 1976 in ...
United States Nuclear Regulatory Commission Office of Nuclear Reactor Regulation
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Chernobyl: The History of the Nuclear Catastrophe by Plokhy Serhii
Kyiv-Mohyla Humanities Journal, 2019 Book review: Plokhy, Serhii. Chernobyl: The History of the Nuclear Catastrophe. New York: Basic Books, 2018. 423 pp.
Mariia Shuvalova
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
An Evaluation of the Annular Fuel and Bottle-Shaped Fuel Concepts for Sodium Fast Reactors
, 2010 Two innovative fuel concepts, the internally and externally cooled annular fuel and the bottle-shaped fuel, were investigated with the goal of increasing the power density and reduce the pressure drop in the sodium-cooled fast reactor, respectively.
Buongiorno, Jacopo +2 more
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