Results 141 to 150 of about 3,482,856 (317)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Supplement no. 1 to the Safety evaluation report by the Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission in the matter of Power Authority of the State of New York, Greene County Nuclear Power Plant, Docket no. 50-549. [PDF]
, 1978 "September 5, 1978."Cover title: Safety evaluation report related to construction of Greene County Nuclear Power Plant, Power Authority of the State of New York. Supplement no. 1."NUREG-0283, Supplement No.
U.S. Nuclear Regulatory Commission. Office of Nuclear Reactor Regulation.
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Nuclear Regulatory Commission Report 0795/errata [PDF]
, 1980 An errata sheet for geomorphic and erosion studies at the Western New York Nuclear Service Center West Valley, New ...
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Nuclear power station project management [PDF]
, 1989 Available from British Library Document Supply Centre- DSC:q89/07356(Nuclear) / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
British Nuclear Energy Society (BNES), London (United Kingdom)
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Análisis del evento causado por la apertura involuntaria de válvulas de seguridad y alivio en la central nuclear de Leibstadt utilizando el código TRACE [PDF]
, 2019 [ES] El objetivo fundamental de los códigos termohidráulicos es simular el comportamiento de un reactor nuclear frente a distintos escenarios, como transitorios de planta y accidentes. El desarrollo de estos códigos ha sido promovido durante mucho tiempo
Blanco-Muelas, David +6 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source