Results 21 to 30 of about 6,280 (278)

From Tactical Utility to Human Cost: The Normative Shift in the Prohibition of Combatant Suffering

Journal for Peace and Nuclear Disarmament
This article examines the evolving interpretation of the principle prohibiting superfluous injury or unnecessary suffering in international humanitarian law (IHL) applicable to combatants.
Jaroslav Krasny
doaj   +1 more source

Strengthening the Biological Weapons Convention: Transparency and Denial as Complementary Approaches

Journal for Peace and Nuclear Disarmament
The Biological Weapons Convention (BWC) remains a cornerstone of international disarmament but faces persistent challenges due to the absence of a verification regime and the dual-use nature of biological research.
Jaroslav Krasny
doaj   +1 more source

Synergistic Effects of Deterrence by Denial and Safeguards in the Biological Weapons Convention: Building on the History of International Nuclear Safeguards

Journal for Peace and Nuclear Disarmament
The notion of deterrence by denial has been introduced in relation to biosecurity. The goal of deterrence by denial in biosecurity extends beyond dissuading attacks. It also encompasses the protection of citizens in the event of an attack.
Kazuko Hikawa
doaj   +1 more source

International relations in the light of agreement on Iran’s nuclear program [PDF]

Војно дело, 2016
Several-year talks between the representatives of the international community and Iran, aiming to place this country’s nuclear program under the control of the International Atomic Energy Agency, ended with signing of the Joint Comprehensive Plan of ...
Bjelica-Vlajić Iris
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Biological Threat Deterrence by Denial: Implications for Japan’s Nuclear Disarmament Vision

Journal for Peace and Nuclear Disarmament
Japan, a proponent of nuclear disarmament, is facing criticism for adopting “nuclear deterrence” as its foreseeable security policy without providing a clear strategy for transitioning away from it.
Kazuko Hikawa
doaj   +1 more source

Membrane estrogen receptor-α contributes to female protection against high-fat diet-induced metabolic disorders

Frontiers in Endocrinology, 2023
BackgroundEstrogen Receptor α (ERα) is a significant modulator of energy balance and lipid/glucose metabolisms. Beyond the classical nuclear actions of the receptor, rapid activation of intracellular signaling pathways is mediated by a sub-fraction of ...
Aurélie Fabre, Blandine Tramunt, Blandine Tramunt, Alexandra Montagner, Céline Mouly, Elodie Riant, Marie-Lou Calmy, Marine Adlanmerini, Coralie Fontaine, Rémy Burcelin, Françoise Lenfant, Jean-François Arnal, Pierre Gourdy, Pierre Gourdy   +13 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Beyond Division in Nuclear Disarmament: An Interview with Ambassador Alexander Kmentt

Journal for Peace and Nuclear Disarmament
Ambassador Alexander Kmentt has led diplomatic work on disarmament, non-proliferation, focusing on the humanitarian impact of nuclear weapons. A key architect of the humanitarian initiative and the TPNW, he chaired the First Meeting of States Parties in ...
Kimiaki Kawai
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source