Results 41 to 50 of about 5,614 (245)

Transitioning from the Nuclear Non-Proliferation Regime to a Future Global Nuclear-Zero Regime: What Legal and Institutional Issues Will the TPNW Need to Address Going Forward?

Journal for Peace and Nuclear Disarmament
Achieving a world without nuclear weapons requires a transition from today’s nuclear non-proliferation regime to a durable nuclear-zero regime. Separating (i) legal and institutional functions of a legal framework from (ii) enabling conditions beyond ...
Michiru Nishida
doaj   +1 more source

End of the INF Treaty: Are We Entering a New Cold War Era?

Gazi Akademik Bakış, 2021
This article analyzes possible consequences of the abolition of the Intermediate-Range Nuclear Forces (INF) Treaty, signed between the US and the USSR in 1987 and banning developing, testing and deploying intermediate-range missiles.
Şafak OĞUZ, Mehmet Seyfettin EROL
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

"Securing our survival (SOS)": non-state actors and the campaign for a nuclear weapons convention through the prism of securitisation theory [PDF]

Brazilian Political Science Review, 2013
This article analyses the security practices of the anti-nuclear movement in the post-Cold War period through the prism of securitisation theory. By exploring Buzan and Wæver's conceptual developments on macrosecuritisations, the practices involved in ...
Renata H. Dalaqua
doaj  

Trump and the Interregnum of American Nuclear Hegemony

Journal for Peace and Nuclear Disarmament, 2018
Nuclear weapons are the ultimate power capacity of states. They make it possible to exterminate whole states, cities and peoples almost instantaneously. Because they are militarily unusable in almost any conceivable context, their main (but not only) use
Peter Hayes
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

What Should the International Non-Proliferation Regime Look Like Today and Over the Next 10 to 20 Years?

Journal for Peace and Nuclear Disarmament
Frustration over the lack of progress in nuclear disarmament under the Nuclear Non-Proliferation Treaty (NPT) led to the creation of the Treaty on the Prohibition of Nuclear Weapons (TPNW). On the other hand, there is criticism that the TPNW has fostered
Andreas Persbo, Kseniia Pirnavskaia
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Introduction: Reducing the Risk of Nuclear Weapons Use in Northeast Asia

Journal for Peace and Nuclear Disarmament
This paper summarises the joint collaborative project between the Nautilus Institute, the Research Center for Nuclear Weapon Abolition, Nagasaki University (RECNA), the Asia Pacific Leadership Network for Nuclear Non-Proliferation and Disarmament (APLN ...
Shatabhisha Shetty
doaj   +1 more source