Results 41 to 50 of about 1,457,964 (285)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Treaty on the Prohibition of Nuclear Weapons: Strengths, Weaknesses and Current Status

Journal for Peace and Nuclear Disarmament
This commentary offers an analysis of the Treaty on the Prohibition of Nuclear Weapons (TPNW), its strengths, weaknesses, relationship to other agreements as well as recent updates.
Jean Krasno, Elisabeth Szeli
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

WAAS Retrospective: Why WAAS?

Cadmus, 2021
In this short article, the author traces the sociological origins of WAAS and traces briefly the history of the scientists‘ nuclear abolition movement, which was a main reason for the founding of the Academy.
Augusto Forti
doaj  

Kan die kernwapenwedloop deur kern-wapenbeheer beëindig word?

Koers : Bulletin for Christian Scholarship, 1983
The slogans of the "walkers for peace " in the Uniled Slates of America anti in Western Europe (and also in South Africa) against the proliferation of nuclear weapons and nuclear technology as well as the growing probability of a nuclear war
A. W. van Tonder
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Transitioning from the Nuclear Non-Proliferation Regime to a Future Global Nuclear-Zero Regime: What Legal and Institutional Issues Will the TPNW Need to Address Going Forward?

Journal for Peace and Nuclear Disarmament
Achieving a world without nuclear weapons requires a transition from today’s nuclear non-proliferation regime to a durable nuclear-zero regime. Separating (i) legal and institutional functions of a legal framework from (ii) enabling conditions beyond ...
Michiru Nishida
doaj   +1 more source

The State of Nuclear Weapons in 2019: Conversations with Experts at the Carnegie International Nuclear Policy Conference

Journal for Peace and Nuclear Disarmament, 2019
Research Center for Nuclear Weapons Abolition, Nagasaki University (RECNA) conducted a series of interviews with nuclear experts on the sidelines of the 2019 Carnegie International Nuclear Policy Conference held in Washington, DC on March 11 and 12, 2019.
Fumihiko Yoshida, Tatsujiro Suzuki
doaj   +1 more source