Results 41 to 50 of about 6,280 (278)

Kan die kernwapenwedloop deur kern-wapenbeheer beëindig word?

Koers : Bulletin for Christian Scholarship, 1983
The slogans of the "walkers for peace " in the Uniled Slates of America anti in Western Europe (and also in South Africa) against the proliferation of nuclear weapons and nuclear technology as well as the growing probability of a nuclear war
A. W. van Tonder
doaj   +1 more source

Vol.9 No.1

, 2020
RECNA Newsletter, 9(1), pp.1-7 ...
Research Center for Nuclear Weapons Abolition (RECNA)
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transitioning from the Nuclear Non-Proliferation Regime to a Future Global Nuclear-Zero Regime: What Legal and Institutional Issues Will the TPNW Need to Address Going Forward?

Journal for Peace and Nuclear Disarmament
Achieving a world without nuclear weapons requires a transition from today’s nuclear non-proliferation regime to a durable nuclear-zero regime. Separating (i) legal and institutional functions of a legal framework from (ii) enabling conditions beyond ...
Michiru Nishida
doaj   +1 more source

The State of Nuclear Weapons in 2019: Conversations with Experts at the Carnegie International Nuclear Policy Conference

Journal for Peace and Nuclear Disarmament, 2019
Research Center for Nuclear Weapons Abolition, Nagasaki University (RECNA) conducted a series of interviews with nuclear experts on the sidelines of the 2019 Carnegie International Nuclear Policy Conference held in Washington, DC on March 11 and 12, 2019.
Fumihiko Yoshida, Tatsujiro Suzuki
doaj   +1 more source

Vol.9 No.2

, 2021
RECNA Newsletter, 9(2), pp.1-8 ...
Research Center for Nuclear Weapons Abolition (RECNA)
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

End of the INF Treaty: Are We Entering a New Cold War Era?

Gazi Akademik Bakış, 2021
This article analyzes possible consequences of the abolition of the Intermediate-Range Nuclear Forces (INF) Treaty, signed between the US and the USSR in 1987 and banning developing, testing and deploying intermediate-range missiles.
Şafak OĞUZ, Mehmet Seyfettin EROL
doaj  

Vol.10 No.1

, 2021
RECNA Newsletter, 10(1), pp.1-9 ...
Research Center for Nuclear Weapons Abolition (RECNA)
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source