Results 41 to 50 of about 5,669 (234)

Transitioning from the Nuclear Non-Proliferation Regime to a Future Global Nuclear-Zero Regime: What Legal and Institutional Issues Will the TPNW Need to Address Going Forward?

Journal for Peace and Nuclear Disarmament
Achieving a world without nuclear weapons requires a transition from today’s nuclear non-proliferation regime to a durable nuclear-zero regime. Separating (i) legal and institutional functions of a legal framework from (ii) enabling conditions beyond ...
Michiru Nishida
doaj   +1 more source

The State of Nuclear Weapons in 2019: Conversations with Experts at the Carnegie International Nuclear Policy Conference

Journal for Peace and Nuclear Disarmament, 2019
Research Center for Nuclear Weapons Abolition, Nagasaki University (RECNA) conducted a series of interviews with nuclear experts on the sidelines of the 2019 Carnegie International Nuclear Policy Conference held in Washington, DC on March 11 and 12, 2019.
Fumihiko Yoshida, Tatsujiro Suzuki
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

End of the INF Treaty: Are We Entering a New Cold War Era?

Gazi Akademik Bakış, 2021
This article analyzes possible consequences of the abolition of the Intermediate-Range Nuclear Forces (INF) Treaty, signed between the US and the USSR in 1987 and banning developing, testing and deploying intermediate-range missiles.
Şafak OĞUZ, Mehmet Seyfettin EROL
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

"Securing our survival (SOS)": non-state actors and the campaign for a nuclear weapons convention through the prism of securitisation theory [PDF]

Brazilian Political Science Review, 2013
This article analyses the security practices of the anti-nuclear movement in the post-Cold War period through the prism of securitisation theory. By exploring Buzan and Wæver's conceptual developments on macrosecuritisations, the practices involved in ...
Renata H. Dalaqua
doaj  

Trump and the Interregnum of American Nuclear Hegemony

Journal for Peace and Nuclear Disarmament, 2018
Nuclear weapons are the ultimate power capacity of states. They make it possible to exterminate whole states, cities and peoples almost instantaneously. Because they are militarily unusable in almost any conceivable context, their main (but not only) use
Peter Hayes
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

What Should the International Non-Proliferation Regime Look Like Today and Over the Next 10 to 20 Years?

Journal for Peace and Nuclear Disarmament
Frustration over the lack of progress in nuclear disarmament under the Nuclear Non-Proliferation Treaty (NPT) led to the creation of the Treaty on the Prohibition of Nuclear Weapons (TPNW). On the other hand, there is criticism that the TPNW has fostered
Andreas Persbo, Kseniia Pirnavskaia
doaj   +1 more source