Results 61 to 70 of about 6,280 (278)

Macmillan's Role in Resolving International Crises (1958-1962)‎ ‎(Selected Models)‎ [PDF]

مجلة جامعة الأنبار للعلوم الإنسانية
Several international crises erupted in which British Prime Minister Harold Macmillan played a distinguished role, especially the second Berlin crisis 1958-1960, as he had an important role in easing tensions through his visit to Moscow Especially after ...
Hussein Hammad Abid, Hanadi Ismael Ibrahim   +1 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Nuclear Weapons Don’t Belong on Our Planet

Journal for Peace and Nuclear Disarmament
In January 2024, the newly appointed Executive Director of the International Campaign to Abolish Nuclear Weapons (ICAN), Melissa Parke, visited Hiroshima and Nagasaki for the first time, where she met with atomic bomb survivors (hibakusha), officials ...
Melissa Parke
doaj   +1 more source

The Treaty is Out of the Bottle: The Power and Logic of Nuclear Disarmament

Journal for Peace and Nuclear Disarmament, 2019
The nuclear genie is out of the bottle, manifesting as nuclear proliferation. Efforts to contain it have generated another genie whose agenda is to establish a verifiable nuclear disarmament regime.
Merav Datan, Jürgen Scheffran
doaj   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Dimensional Consistency in Korean Terminology for Force, Energy, and Power in Climate, Energy, and Environmental Fields: A Review [PDF]

대한환경공학회지
In modern climate, energy, and environmental fields, optimizing energy efficiency and utilizing renewable energy resources have become central challenges.
Sokhee P. Jung
doaj   +1 more source

The Ideology of Nuclear Order

, 2021
The “global nuclear order” is commonly understood as an evolving set of institutions, norms, and practices governing the development and use of nuclear technology worldwide.
Egeland, Kjolv
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source