Results 81 to 90 of about 5,669 (234)

Re-examining the 1996 ICJ Advisory Opinion: Concerning the Legality of Nuclear Weapons

Cadmus, 2012
The primary objections raised against total elimination of nuclear weapons are built around a few arguments mostly of non-technical nature.Nuclear weapons and the strategies for their use have resulted in the establishment of a vicious circle within ...
Jasjit Singh
doaj  

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

The Nuclear Dilemma in a 360-Degree Context

Journal for Peace and Nuclear Disarmament
In the context of the breakdown of nuclear arms control, the crisis of world order and the background of ecological disruption, this commentary discusses key aspects of a possible world order that can achieve and sustain the abolition of nuclear weapons.
Dan Smith
doaj   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

The Power Sector of Ukraine: Collapse or Survival [PDF]

Problemi Ekonomiki, 2018
There considered the state of the basic traditional power industries of the Ukrainian economy: hydropower, nuclear, thermal one, which were put into operation as far back as in the time of the planned economy.
Skrypnyk Andrii V. , Namiasenko Yurii O. , Sabishchenko Oleksandr V.   +2 more
doaj  

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Notes on Nuclear Weapons: Toward Abolition or Armageddon?

Asia-Pacific Journal, 2012
People still clearly remember that on April 5, 2009 the U.S. President Barack Obama excited an audience in Prague by declaring that his government “will take concrete steps towards a world without nuclear weapons.” As the only nuclear power to have ever used a nuclear weapon, he said, the United States has a moral responsibility to act. Indeed, the U.S.
openaire   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Extended Nuclear Deterrence, Global Abolition, and Korea

Asia-Pacific Journal, 2009
This essay examines the role that nuclear weapons have played in Northeast Asia in creating a system of inter-state relations based in part on nuclear threat and the impact of North Korea on that system. The US-led alliances that rest on extended nuclear deterrence have been characterized as hegemonic in the forty years of Cold War in the Gramscian ...
openaire   +1 more source