The Importance of Radiopharmaceutical Chemistry for the Development of Nuclear Medicine: a Message from the Associate Editor [PDF]
, 2015 Jae Min Jeong
openalex +1 more source
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry.
Analytical Chemistry, 2018 B. Plainchont +4 more
semanticscholar +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
RAPPORT EUROPEES CONGRES TOEGEPASTE ELECTRONEN‐MICROSCOPIE/HALBLEITERPROBLEME II/REPORTS ON PROGRESS IN PHYSICS/DIE ATOMWIRTSCHAFT/ATOMKERNENERGIE/ATOMPRAXIS/JOURNAL OF NUCLEAR ENERGY/JOURNAL OF INORGANIC AND NUCLEAR CHEMISTRY/JOURNAL FÜR PRAKTISCHE CHEMIE/FORSCHUNGSFILM [PDF]
, 1956 O. Rang, W. Hanle, Werner Hinsch
openalex +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Atomic number and isotopy before nuclear structure: multiple standards and evolving collaboration of chemistry and physics [PDF]
, 2022 Jordi Cat, Nicholas W. Best
openalex +1 more source