Results 81 to 90 of about 3,270,734 (378)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Spatially Resolved Chemistry in Nearby Galaxies I. The Center of IC 342

, 2004
We have imaged emission from the millimeter lines of eight molecules--C2H, C34S, N2H+, CH3OH, HNCO, HNC, HC3N, and SO--in the central half kpc of the nearby spiral galaxy IC 342. The 5" (~50 pc) resolution images were made with OVRO.
Athanassoula E., Brouillet N., Chin Y.-N., Chung H. S., Dahmen G., David S. Meier, de Vicente P., Demyk K., Dickinson A. S., Downes D., Friberg P., Fuente A., Garcia-Burillo S., Hasegawa T. I., Heikkila A., Heithausen A., Henkel C., Henkel C., Henkel C., Ho P. T. P., Hudson R. L., Huggins P. J., Huttemeister S., Huttemeister S., Huttemeister S., Huttemeister S., Jean L. Turner, Kalenskii S. V., Kalenskii S. V., Lapinov A. V., Lucas R., Mauersberger R., Mauersberger R., Mauersberger R., Mauersberger R., Mauersberger R., Mauersberger R., Mauersberger R., Mauersberger R., Menten K. M., Millar T. J., Morata O., Nguyen, Nguyen, Nilsson A., Nyman L.-A., Nyman L.-A., Sandell G., Schilke P., Schutte W. A., Sorai K., Takano S., Talbi D., Talbi D., Truong-Bach, Watt G. D., Watt G. D., Wilson T. L., Zinchenko I.   +58 more
core   +1 more source

A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy [PDF]

, 2015
A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented.
Cronin, Leroy, Dragone, Vincenza, Porwol, Luzian, Sans Sangorrin, Victor   +3 more
core   +2 more sources

An introduction to serious nuclear accident chemistry

, 2015
A review of the chemistry occurring inside a nuclear power plant during a serious reactor accident is presented. This includes some aspects of the behavior of nuclear fuel, its cladding, cesium and iodine.
M. Foreman
semanticscholar   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Nitrido Technetium-99 m Core in Radiopharmaceutical Applications: Four Decades of Research

Inorganics, 2019
The knowledge on element 43 (Tc) of the periodic table, built over the years through the contributions given by the close relationship between chemistry and nuclear medicine, allowed the development of new and increasingly effective radiopharmaceuticals ...
Cristina Bolzati, Alessandro Dolmella
doaj   +1 more source

Climate and chemistry effects of a regional scale nuclear conflict [PDF]

Atmospheric Chemistry and Physics, 2013
Previous studies have highlighted the severity of detrimental effects for life on earth after an assumed regionally limited nuclear war. These effects are caused by climatic, chemical and radiative changes persisting for up to one decade. However, so far
A. Stenke, C. R. Hoyle, B. Luo, E. Rozanov, J. Gröbner, L. Maag, S. Brönnimann, T. Peter   +7 more
doaj   +1 more source

Activation cross-section data for alpha-particle induced nuclear reactions on natural ytterbium for some longer lived radioisotopes [PDF]

J. Radioanalytical and Nuclear Chemistry 311(3)(2017)1825-1829, 2018
Additional experimental cross sections were deduced for the long half-life activation products (172Hf and 173Lu) from the alpha particle induced reactions on ytterbium up to 38 MeV from late, long measurements and for 175Yb, 167Tm from a re-evaluation of earlier measured spectra.
arxiv   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy

Pharmaceutics, 2019
To date, our understanding of the Substance P (SP) and neurokinin 1 receptor (NK1R) system shows intricate relations between human physiology and disease occurrence or progression.
Agnieszka Majkowska-Pilip, Paweł Krzysztof Halik, Ewa Gniazdowska   +2 more
doaj   +1 more source