Results 161 to 170 of about 5,041,695 (380)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Natural infection with Fasciola hepatica (Linnaeus, 1758) in the European bison (Bison bonasus) in Białowieża National Park, Poland

Helminthologia, 2013
Kiziewicz B.
doaj   +1 more source

TESTING A NEW NUCLEAR DNA MARKER FOR STUDIES OF HYBRIDIZATION IN SPECKLED (SPERMOPHILUS SUSLICUS GÜLD.) AND LARGE GROUND SQUIRRELS

, 2018
С. В. Титов, A. A. Kuzmin, S. S. Zaks, O. V. Chernyshova   +3 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Rewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control

EMBO Molecular Medicine
Mitochondrial diseases, caused by mutations in nuclear or mitochondrial DNA (mtDNA), have limited treatment options. For mtDNA mutations, reducing the mutant-to-wild-type mtDNA ratio (heteroplasmy shift) is a promising strategy, though it currently faces
María J Pérez, Rocío B Colombo, Sebastián M Real, María T Branham, Sergio R Laurito, Carlos T Moraes, Lía Mayorga   +6 more
doaj   +1 more source

Shutoff of Host RNA Synthesis in Bacteriophage T4-Infected Escherichia coli in the Absence of Host DNA Degradation and Nuclear Disruption [PDF]

, 1977
D. Peter Snustad, C J Bursch
openalex   +1 more source

Targeting Nuclear NAD+ Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells [PDF]

, 2020
Alexandra Kiss, Arnold Péter Ráduly, Zsolt Regdon, Zsuzsanna Polgár, Szabolcs Tarapcsák, Isotta Sturniolo, Tarek El‐Hamoly, László Virág, Csaba Hegedűs   +8 more
openalex   +1 more source

Nuclear DNA [PDF]

, 2020
openaire   +1 more source

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress.

Proceedings of the National Academy of Sciences of the United States of America, 1997
F. Yakes, B. V. Houten
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source