Results 11 to 20 of about 1,547,221 (287)

In vitro assessment of the severity of deoxyribonucleic acid damage in different types of cataracts directly in lens epithelial cells

open access: yesIndian Journal of Ophthalmology, 2023
Purpose: This study aimed to assess the severity of deoxyribonucleic acid (DNA) damage in lens epithelial cells (LECs) of senile cortical, nuclear, and posterior subcapsular cataracts.
Kranti S Sorte Gawali, Avinash N Jadhao
doaj   +1 more source

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. [PDF]

open access: yes, 2018
The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair
Alshareeda   +64 more
core   +2 more sources

Molecular taxonomy of the Sympetrum vulgatum (Odonata: Libellulidae) complex in the West Palaearctic

open access: yesEuropean Journal of Entomology, 2017
The Sympetrum vulgatum (Linnaeus, 1758) complex is composed of the subspecies S. vulgatum vulgatum, S. vulgatum decoloratum (Selys, 1884) and S. vulgatum ibericum Ocharan, 1985 in the West Palaearctic.
Joan C. HINOJOSA   +3 more
doaj   +1 more source

DNA Double-Strand Breaks Induce the Nuclear Actin Filaments Formation in Cumulus-Enclosed Oocytes but Not in Denuded Oocytes. [PDF]

open access: yesPLoS ONE, 2017
As a gamete, oocyte needs to maintain its genomic integrity and passes this haploid genome to the next generation. However, fully-grown mouse oocyte cannot respond to DNA double-strand breaks (DSBs) effectively and it is also unable to repair them before
Ming-Hong Sun   +7 more
doaj   +1 more source

Development of conventional PCR and a Real-Time PCR assay to choose the most suitable method for residual DNA identification of Beluga, Huso huso, in concrete fish ponds [PDF]

open access: yesCaspian Journal of Environmental Sciences
A unique research was developed to achieve an effective and efficient method for tracing and identifying Beluga sturgeon species, Huso huso using eDNA in concrete fish ponds.
Esmaeil Noghanchi Sabet   +2 more
doaj   +1 more source

When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response

open access: yesFrontiers in Cell and Developmental Biology, 2022
The mechanisms that maintain genome stability are critical for preventing tumor progression. In the past decades, many strategies were developed for cancer treatment to disrupt the DNA repair machinery or alter repair pathway selection.
Yu-Hsiu Wang, Michael P. Sheetz
doaj   +1 more source

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. [PDF]

open access: yes, 2019
Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle.
Bannister   +77 more
core   +1 more source

RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]

open access: yes, 2020
Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe   +4 more
core   +1 more source

Effect of the Compaction and the Size of DNA on the Nuclear Transfer Efficiency after Microinjection in Synchronized Cells

open access: yesPharmaceutics, 2015
The nuclear transfer process is one of the critical rate-limiting processes in transgene expression. In the present study, we report on the effect of compaction and the size of the DNA molecule on nuclear transfer efficiency by microinjection.
Hidetaka Akita   +4 more
doaj   +1 more source

Early Steps of Hepatitis B Life Cycle: From Capsid Nuclear Import to cccDNA Formation

open access: yesViruses, 2021
Hepatitis B virus (HBV) remains a major public health concern, with more than 250 million chronically infected people who are at high risk of developing liver diseases, including cirrhosis and hepatocellular carcinoma.
João Diogo Dias   +2 more
doaj   +1 more source

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