Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. [PDF]
, 2019 The maintenance of genomic integrity is essential for normal cellular functions. However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with age and is exacerbated by multiple neurological
Adame, Anthony +8 more
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Circular DNA's from HeLa cell nuclei and mitochondria [PDF]
, 1970 An electron microscopic observation was made on the DNA's extracted from purified HeLa cell nuclei, mitochondria, and the whole cell, and fractionated by ethidium bromide-cesium chloride density gradient method or sucrose density gradient method. Nuclear
Hirata, Seiichi +4 more
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Archaic mitochondrial DNA inserts in modern day nuclear genomes
, 2019 Traces of interbreeding of Neanderthals and Denisovans with modern humans in the form of archaic DNA have been detected in the genomes of present-day human populations outside sub-Saharan Africa.
Bücking, R. +5 more
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Frontiers in Microbiology, 2015 DNA viruses undertake their replication within the cell nucleus, and therefore they must first deliver their genome into the nucleus of their host cells. Thus, trafficking across the nuclear envelope is at the basis of DNA virus infections.
Nikta eFay, Nelly ePante
doaj +1 more source
Mitochondrial Dna Replacement Versus Nuclear Dna Persistence
, 2006 In this paper we consider two populations whose generations are not overlapping and whose size is large. The number of males and females in both populations is constant.
Cann R L +6 more
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Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle [PDF]
, 2017 The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is a sequence-specific DNA binding protein which plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of DNA replication onto the origin (oriP) and
Baillie, George S. +11 more
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Inflammation, DNA-centered radicals, and oxidative genotoxicity: The role of HOCl produced by myeloperoxidase in carcinogenesis [PDF]
, 2009 Myeloid cells (macrophages and neutrophils) infiltrate and synthesize myeloperoxidase (MPO) in sites of inflammation, producing gentotoxicity. In RAW 264.7 macrophages, bacterial lipopolysaccharide (LPS) induces superoxide radical anion, nuclear ...
Dario C. Ramirez +2 more
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Tomato protoplast DNA transformation: physical linkage and recombination of exogenous DNA sequences [PDF]
, 1987 Tomato protoplasts have been transformed with plasmid DNA's, containing a chimeric kanamycin resistance gene and putative tomato origins of replication.
A Crossway +38 more
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Mitochondrial-nuclear DNA interactions contribute to the regulation of nuclear transcript levels as part of the inter-organelle communication system. [PDF]
PLoS ONE, 2012 Nuclear and mitochondrial organelles must maintain a communication system. Loci on the mitochondrial genome were recently reported to interact with nuclear loci.
Chris D M Rodley +5 more
doaj +1 more source
Genotoxic agents promote the nuclear accumulation of annexin A2: role of annexin A2 in mitigating DNA damage [PDF]
, 2012 Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma membrane, however a small population has been found in the nucleus, suggesting a nuclear function for the protein.
A Hofmann +58 more
core +3 more sources