Results 81 to 90 of about 5,041,695 (380)

Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA

Nature Communications
Nuclear Factor IA, a member of the long-studied Nuclear Factor I family of DNA-binding proteins, plays pivotal roles in development and metabolism. Dysregulation or loss of Nuclear Factor IA is associated with severe neurological defects in humans and ...
Ci Zhu, Ding Xiao, Zhipu Luo, Jie Zhang, Shuang Liu, Yueyu Wang, Xi Chen, Hejin Xiao, Xiaofeng Li, Juyu Tang, Xianyang Fang, Jie Shen, He Song   +12 more
doaj   +1 more source

Perturbation of host nuclear membrane component RanBP2 impairs the nuclear import of human immunodeficiency virus -1 preintegration complex (DNA). [PDF]

PLoS ONE, 2010
HIV-1 is a RNA virus that requires an intermediate DNA phase via reverse transcription (RT) step in order to establish productive infection in the host cell.
Ruonan Zhang, Rajeev Mehla, Ashok Chauhan   +2 more
doaj   +1 more source

Investigations into the molecular effects of single nucleotide polymorphism [PDF]

, 2000
Objectives: DNA sequences are very rich in short repeats and their pattern can be altered by point mutations. We wanted to investigate the effect of single nucleotide polymorphism (SNP) on the pattern of short DNA repeats and its biological consequences.
Lohrer, Horst D., Tangen, Uwe
core   +1 more source

Human Tribbles 3 Protects Nuclear DNA from Cytidine Deamination by APOBEC3A*

Journal of Biological Chemistry, 2012
Background: APOBEC3A can hyperedit nuclear DNA and generates double-stranded DNA breaks. Results: TRIB3 is an interactor for APOBEC3A and APOBEC3C. TRIB3 is a negative regulator of APOBEC3A.
M. Aynaud, R. Suspène, P. Vidalain, Bianka Mussil, D. Guétard, F. Tangy, S. Wain-Hobson, J. Vartanian   +7 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Testing robustness of relative complexity measure method constructing robust phylogenetic trees for Galanthus L. Using the relative complexity measure [PDF]

, 2013
Background: Most phylogeny analysis methods based on molecular sequences use multiple alignment where the quality of the alignment, which is dependent on the alignment parameters, determines the accuracy of the resulting trees.
Bakis, Yasin, Bakış, Yasin, Bilgin, Nese, Bilgin, Neşe, Meydan, Cem, Otu, Hasan H., Sezerman, Ugur, Sezerman, Uğur, Tasci, Nivart, Taşçı, Nivart, Yuzbasioglu, Sirri, Yüzbaşıoğlu, Sırrı   +11 more
core   +2 more sources

Noninsulin‐dependent diabetes mellitus: effects on sperm morphological and functional characteristics, nuclear DNA integrity and outcome of assisted reproductive technique

Andrologia, 2012
The aim of the study was to compare the semen characteristics and nuclear DNA fragmentation in spermatozoa of diabetic and nondiabetic men undergoing assisted reproduction and correlate them with pregnancy outcome.
Rama Raju Achyuta Gottumukkala, G. Jaya Prakash, K. Murali Krishna, K. Madan, T. Siva Narayana, C. Ravi Krishna   +5 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Dynamics of Metal Centers Monitored by Nuclear Inelastic Scattering

, 2005
Nuclear inelastic scattering of synchrotron radiation has been used now since 10 years as a tool for vibrational spectroscopy. This method has turned out especially useful in case of large molecules that contain a M\"ossbauer active metal center.
A. Becke, A. I. Chumakov, A. McLean, A. Schaefer, A. Schaefer, A. Silvestri, A. Wachters, A. X. Trautwein, A.I. Chumakov, B.M. Leu, C. Schmidt, G. Barone, G. Barone, G. La Manna, H. Paulsen, H. Paulsen, H. Paulsen, H. Paulsen, H. Paulsen, H. Winkler, I. Sergueev, J. A. Wolny, J. Binkley, J. Kusz, J.T. Sage, K. Achterhold, K. Dobbs, K. Dobbs, K. Dobbs, L. H. Böttger, M. Gordon, M. Seto, O. Zakharieva, P. Hay, P. Wegner, R. Czernuszewicz, R. Krishnan, R. Rüffer, T. Asthalter, T. Cundari, U.A. Jayasooriya, V. Schünemann, V.S. Oganesyan, W. Pietro, W. Stevens, W. Stevens, W. Stuhrhahn   +46 more
core   +1 more source

Nuclear tau and its potential role in Alzheimer’s disease [PDF]

, 2016
Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra, Bukar Maina, Mahmoud, Serpell, Louise   +2 more
core   +2 more sources