Results 41 to 50 of about 137,819 (261)

Control system design and simulation of HPR1000

open access: yesNuclear Engineering and Technology
Proportional-integral-derivative (PID) control is widely employed in pressurized water reactor (PWR) systems due to its simplicity and robustness. However, tuning for China's third-generation nuclear reactor, the Hualong Pressurized Reactor (HPR1000 ...
Longhao Xiao   +5 more
doaj   +1 more source

Multi-scale computer-aided design and photo-controlled macromolecular synthesis boosting uranium harvesting from seawater

open access: yesNature Communications, 2022
Developing materials for uranium harvesting from seawater with high adsorption capacity remains challenging. Here, the authors develop a new protocol, by combining multi-scale computational simulations with the PET-RAFT polymerization, for rational ...
Zeyu Liu   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Study on the operation scheme of a pool-type lead-bismuth fast reactor

open access: yesNuclear Engineering and Technology
The small lead-bismuth fast reactor has become one of the main reactor types in the Generation IV reactor because of its high inherent safety and easy miniaturization.
Muping Li   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Analysis of Aerodynamic Heating Modes in Thermochemical Nonequilibrium Flow for Hypersonic Reentry

open access: yesEnergies
Thermochemical nonequilibrium significantly affects the accurate simulation of the aerothermal environment surrounding a hypersonic reentry vehicle entering Earth’s atmosphere during deep space exploration missions.
Shuai He   +8 more
doaj   +1 more source

Challenging energy engineering undergraduates with diverse perspectives on nuclear power

open access: yes, 2021
As part of an introductory energy engineering undergraduate module at University College Cork, student presentations on a zero-carbon energy plan for Ireland have shown a high preference for nuclear energy, despite a complete absence of nuclear energy from the same module curriculum.
Rogan, Fionn   +5 more
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Triboelectrochemical Performance of Electron Beam–Melted Ti-6Al-4V-ELI for Biomedical Applications

open access: yesAdvances in Materials Science and Engineering
Titanium alloys have been widely used for biomaterials’ production due to their high physicochemical stability, mechanical resistance, and biocompatibility.
E. F. Pieretti   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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